Browsing Faculté de médecine by Affiliation "Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie"
Now showing items 21-40 of 50
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Further characterization and determination of the single amino acid change in the tsI138 reovirus thermosensitive mutant
(NRC Research Press, 2012-05)Many temperature-sensitive mutants have been isolated in early studies of mammalian reovirus. However, the bio- logical properties and nature of the genetic alterations remain incompletely explored for most of these mutants. The mutation harbored by ... -
La génétique inverse dans l'étude des réovirus: Progrès, obstacles et développements futurs
(John Libbey Eurotext, 2011-01)En génétique dite « classique », l’examen d’un phénotype conduit à l’étude des gènes impliqués dans son obtention. La génétique inverse est une méthode expérimentale très puissante dans laquelle, au contraire, le matériel génétique est modifié et utilisé ... -
HIV-1 envelope glycoprotein amino acids signatures associated with clade B transmitted/founder and recent viruses
(MDPI, 2019-11-01)Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude of virions present during transmission. They possess the capacity to establish infection and viral dissemination in a new host. Deciphering ... -
HIV-1 envelope sequence-based diversity measures for identifying recent infections
(Public Library of Science, 2017-12-28)Identifying recent HIV-1 infections is crucial for monitoring HIV-1 incidence and optimizing public health prevention efforts. To identify recent HIV-1 infections, we evaluated and compared the performance of 4 sequence-based diversity measures including ... -
HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest
(2010)HIV-1 viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by a mechanism involving the activation of the DNA damage sensor ATR. We and others recently showed that Vpr performs this function by subverting the activity of the DDB1-CUL4A ... -
HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing
(2010)HIV upregulates cell-surface expression of specific ligands for the activating NKG2D receptor, including ULBP-1, -2, -3, but not MICA or MICB, in infected cells both in vitro and in vivo. However, the viral factor(s) involved in NKG2D ligand expression ... -
Humoral responses to the measles, mumps and rubella vaccine are impaired in Leigh Syndrome French Canadian patients
(Public Library of Science, 2020-10-21)Leigh Syndrome French Canadian (LSFC) is a rare autosomal recessive metabolic disorder characterized by severe lactic acidosis crises and early mortality. LSFC patients carry mutations in the Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) ... -
Identification of glycosylation sites essential for surface expression of the Caᵥα2δ1 subunit and modulation of the Cardiac Caᵥ1.2 channel activity
(Elsevier, 2016-02-26)Alteration in the L-type current density is one aspect of the electrical remodeling observed in patients suffering from cardiac arrhythmias. Changes in channel function could result from variations in the protein biogenesis, stability, post-translational ... -
IL23R (Interleukin 23 Receptor) variants protective against inflammatory bowel diseases (IBD) display loss of functiondue to impaired protein stability and intracellular trafficking
(Elsevier, 2016)Genome-wide association studies as well as murine models have shown that the interleukin 23 receptor (IL23R) pathway plays a pivotal role in chronic inflammatory diseases such as Crohn disease (CD), ulcerative colitis, psoriasis, and type 1 diabetes. ... -
Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer
(Frontiers media, 2013-01-13)A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological ... -
LILAC pilot study : effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
(Elsevier, 2021-03-01)Background: Chronic inflammation and residual HIV transcription persist in people living with HIV (PLWH) receiving antiretroviral therapy (ART), thus increasing the risk of developing non-AIDS co-morbidities. The mechanistic target of rapamycin (mTOR) ... -
Longitudinal changes in HIV-specific IFN-? secretion in subjects who received Remune™ vaccination prior to treatment interruption
(2006)BACKGROUND:Despite the benefits of highly active antitretroviral therapy (HAART) for suppressing viral replication in HIV infection, virus persists and rebounds during treatment interruption (TI). This study explored whether HAART intensification with ... -
Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes
(Public Library of Science, 2017-05-01)Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they promote the development of type 2 diabetes is unknown. The effect of chronic ... -
Multiple proteins differing between laboratory stocks of mammalian orthoreoviruses affect both virus sensitivity to interferon and induction of interferon production during infection
Reovirus proteins affecting interferon sensitivity and induction
(2018-01-31)In the course of previous works, it was observed that the virus laboratory stock (T3DS) differs in sequence from the virus encoded by the ten plasmids currently in use in many laboratories (T3DK), and derived from a different original virus stock. ... -
Nearby construction impedes the progression to overt autoimmune diabetes in NOD mice
(Hindawi, 2013)Construction nearby animal houses has sporadically been reported to affect various aspects of animal health. Most of the reports have focussed on the impact on stress hormone levels and the hypersensitivity of animals relative to humans. There has ... -
The NOD mouse beyond autoimmune diabetes
(Frontiers Media, 2022-04-29)Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the pathophysiology of this disease shares many similarities with human type 1 diabetes. Since its generation in 1980, the NOD mouse, derived from the Cataract Shinogi ... -
OCA-B does not act as a transcriptional coactivator in T cells
(Wiley, 2022-05-01)Pou2af1 encodes for OCA-B, a coactivator of OCT-1/2 transcription factors, which plays a key role in B-cell maturation. The function of OCA-B has also been studied in T cells, where T cells from Pou2af1−/− mice have impaired functions, such as cytokine ... -
The potential causes of cystic fibrosis-related diabetes
(Frontiers media, 2021-07-30)Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity, affecting more than 50% of adult CF patients. ... -
Restoring T cell homeostasis after allogeneic stem cell transplantation; principal limitations and future challenges
(Frontiers Media, 2018-06-18)For several leukemia patients, allogeneic stem cell transplantation (allogeneic-SCT) is the unique therapeutic modality that could potentially cure their disease. Despite significant progress made in clinical management of allogeneic-SCT, acute ... -
Revisiting the prominent anti-tumoral potential of pre-mNK cells
(Frontiers Media, 2013-12-11)Interferon-producing killer dendritic cells (IKDC) were first described for their outstanding anti-tumoral properties.The “IKDC” terminology implied the description of a novel DC subset and initiated a debate on their cellular lineage origin.This ...