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Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly
(Elsevier, 2019-08-29)
We present chitosan hydrogel microfluidic devices with self-assembled complex
microcapillary patterns, conveniently formed by a diffusion-reaction process.
These patterns in chitosan hydrogels are formed by a single-step ...
Etude des propriétés physicochimiques des vecteurs nanoparticulaires
(2009-12-03)
Cette thèse rapporte l’étude des propriétés physicochimiques des nanoparticles polymériques et leur impact sur l’interaction avec les cellules vivantes. Nous nous sommes tout spécialement attachés à étudier l’effet des ...
Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin
(Elsevier, 2019-02-27)
We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG ...
Coiled-coil affinity-based system for the controlled release of biofunctionalized gold nanoparticles from alginate hydrogels
(American Chemical Society, 2019-04-05)
Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled coil affinity pair to mediate the ...
Nonspecific interactions in biomedical applications
(Elsevier, 2019-12-20)
Nonspecific interactions play a major role in the microscale functioning of biological units. Exploiting these interactions in design and application of biomedical systems has been beneficial in different branches of ...
Short-sequence superadhesive peptides with topologically en-hanced cation-π interactions
(American Chemical Society, 2021-06-03)
In this study, using the surface force apparatus, we report engineered peptides with short sequences of phenylalanine (F) and lysine (K) amino acids capable of forming the most efficient cation−π interactions reported for ...
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)
The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic ...
Biomimetic bottle-brush polymer coatings for fabrication of ultra-low fouling surfaces
(Wiley, 2018-11-13)
The increasing demand for long lasting antifouling surfaces has steered the development of accessible, novel, biocompatible and environmentally-friendly materials. Inspired by lubricin (LUB), a component of mammalian ...
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
(American Chemical Society, 2018-11-21)
We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid
and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial
fluid is composed of sodium ...
(In)stability of ligands at the surface of inorganic nanoparticles : a forgotten question in nanomedicine?
(Elsevier, 2022-06-14)
Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine. Various core materials and shapes are explored, but they all display a common hybrid structure, with organic ligands on their surface. ...