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Now showing items 21-30 of 34
Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
(Elsevier, 2018-10-11)
We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile ...
Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
(American Chemical Society, 2018-01-29)
Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block ...
Quantification of peptides in human synovial fluid using liquid chromatography–tandem mass spectrometry
(Elsevier, 2018-04-06)
A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides ...
Bioinspired microstructures of chitosan hydrogel provide enhanced wear protection
(Royal Society of Chemistry, 2018-02-16)
We describe the fabrication of physical chitosan hydrogels exhibiting a layered structure. This
bilayered structure, as shown by SEM and confocal microscopy, is composed of a thin dense
superficial zone (SZ), covering a ...
Utilisation des anti-infectieux chez la femme enceinte et issues indésirables de grossesse (avortement spontané, malformations congénitales et faible poids à la naissance)
(2018-05-09)
Les infections en général sont très fréquentes durant la grossesse. A titre exemple, la prévalence des infections urinaires gravidiques se situe entre 2 à 10 %. Une femme enceinte ayant une bactériurie asymptomatique ...
Nanoparticle heterogeneity : an emerging structural parameter 2 influencing particle fate in biological media?
(Royal Society of Chemistry, 2018-11-27)
Drug nanocarriers’ surface chemistry is often presumed to be uniform. For instance, the polymer surface coverage and distribution of ligands on nanoparticles are described with averaged values obtained from quantification ...
Intermolecular interactions between Bottlebrush Polymers boost the protection of surfaces against frictional wear
(ACS Publications, 2018-05-30)
Polymers exhibiting the bottlebrush (BB) architecture have excellent lubricating properties. However, to motivate their use in real life systems, they must also protect surfaces against frictional damage. In this article, ...
Étude de l’influence de différentes méthodes de fabrication sur l’architecture et les propriétés physico-chimiques des nanoparticules à base de PEG-b-PLA
(2018-03-23)
Les nanoparticules polymériques permettent d’améliorer la biodistribution et la stabilité des principes actifs. Leur performance in vivo est étroitement reliée à leurs propriétés physico-chimiques, donc il est important ...
Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery
(Taylor & Francis, 2018-11-13)
Inflammatory mechanisms are activated, and thrombotic complications occur during the initial
months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet
activation and platelet–leukocyte ...
Preparedness for the next epidemic : health and political issues of an emerging paradigm
(Taylor & Francis, 2018-03-08)
‘Preparing for the next epidemic’ has been a recurrent theme in global
health in recent years. Starting with SARS, by way of the Avian influenza, and
intensifying after the 2013–2016 Ebola outbreak, the urgency of ...