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Is nontargeted data acquisition for target analysis (nDATA) in mass spectrometry a forward-thinking analytical approach?
(Wiley, 2022-10-21)
Targeted mass spectrometry is extensively used for the quantitative measurement of various molecules present in complex matrices. It is certainly one of the most important analytical duties in a mass spectrometry laboratory. ...
Assessment of Tandem Mass Spectrometry and High Resolution Mass Spectrometry for the Analysis of Bupivacaine in Plasma
(2015-11-01)
Triple quadrupole mass spectrometers coupled with high performance liquid chromatography are
workhorses in quantitative bioanalyses. It provides substantial benefits including reproducibility,
sensitivity and selectivity ...
In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry
(2014-12-01)
Ketamine is widely used in medicine in combination with several benzodiazepines including
midazolam. The objectives of this study were to develop a novel HPLC-MS/SRM method
capable of quantifying ketamine and norketamine ...