Browsing Faculté de médecine vétérinaire by Author "Nkambeu, Bruno"
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Antinociceptive activity of vanilloids in caenorhabditis elegans is mediated by the desensitization of the TRPV channel OCR-2 and specific signal transduction pathways
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (Springer, 2023-02-03)Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged treatment with vanilloids triggered the desensitization of TRPV1, leading to analgesic or antinociceptive ... -
Cannabidiol and tetrahydrocannabinol antinociceptive activity is mediated by distinct receptors in caenorhabditis elegans
Boujenoui, Fatma; Nkambeu, Bruno; Ben Salem, Jennifer; Castaño Uruena, Jesus David; Beaudry, Francis (Springer, 2023-11-22)Cannabis has gained popularity in recent years as a substitute treatment for pain following the risks of typical treatments uncovered by the opioid crisis. The active ingredients frequently associated with pain-relieving effects are the phytocannabinoids ... -
Capsaicin and Its analogues impede nocifensive response of caenorhabditis elegans to noxious heat
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (2020-05-05)Capsaicin is the most abundant pungent molecule identifed in red chili peppers, and it is widely used for food favoring, in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and several other ... -
Études comparatives de la nociception chez Caenorhabditis elegans souche sauvage (N2) et mutants (egl-3 et egl-21)
Nkambeu, Bruno (2019-03-21)L’objectif de cette étude était de vérifier l’hypothèse selon laquelle, les mutants C. elegans (egl-3, egl-21, flp-18 et flp-21) auraient une diminution significative dans la production de neuropeptides matures bioactifs et présenteraient donc une ... -
Eugenol and other vanilloids hamper caenorhabditis elegans response to noxious heat
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (Springer, 2020-10-29)Eugenol, a known vanilloid, was frequently used in dentistry as a local analgesic in addition, antibacterial and neuroprotective effects were also reported. Eugenol, capsaicin and many vanilloids are interacting with the transient receptor potential ... -
Impaired EAT-4 vesicular glutamate transporter leads to defective nocifensive response of caenorhabditis elegans to noxious heat
Leonelli, Sophie; Nkambeu, Bruno; Beaudry, Francis (Springer, 2019-04-26)In mammals, glutamate is an important excitatory neurotransmitter. Glutamate and glutamate receptors are found in areas specifically involved in pain sensation, transmission and transduction such as peripheral nervous system, spinal cord and brain. ... -
Resiniferatoxin hampers the nocifensive response of Caenorhabditis elegans to noxious heat, and pathway analysis revealed that the Wnt signaling pathway is involved
Ben Salem, Jennifer; Nkambeu, Bruno; Arvanitis, Dina N.; Beaudry, Francis (Springer, 2021-10-25)Resiniferatoxin (RTX) is a metabolite extracted from Euphorbia resinifera. RTX is a potent capsaicin analog with specific biological activities resulting from its agonist activity with the transient receptor potential channel vanilloid subfamily member ...