Parcourir Faculté de médecine vétérinaire par auteur·e "Ben Salem, Jennifer"
Voici les éléments 1-8 de 8
-
Anandamide modulates thermal avoidance in caenorhabditis elegans through vanilloid and cannabinoid receptor interplay
Abdollahi, Marzieh; Ben Salem, Jennifer; Castaño Uruena, Jesus David; Beaudry, Francis (Springer, 2024-03-27)Understanding the endocannabinoid system in C. elegans may offer insights into basic biological processes and potential therapeutic targets for managing pain and inflammation in human. It is well established that anandamide modulates pain perception ... -
Antinociceptive activity of vanilloids in caenorhabditis elegans is mediated by the desensitization of the TRPV channel OCR-2 and specific signal transduction pathways
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (Springer, 2023-02-03)Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged treatment with vanilloids triggered the desensitization of TRPV1, leading to analgesic or antinociceptive ... -
Cannabidiol and tetrahydrocannabinol antinociceptive activity is mediated by distinct receptors in caenorhabditis elegans
Boujenoui, Fatma; Nkambeu, Bruno; Ben Salem, Jennifer; Castaño Uruena, Jesus David; Beaudry, Francis (Springer, 2023-11-22)Cannabis has gained popularity in recent years as a substitute treatment for pain following the risks of typical treatments uncovered by the opioid crisis. The active ingredients frequently associated with pain-relieving effects are the phytocannabinoids ... -
Capsaicin and Its analogues impede nocifensive response of caenorhabditis elegans to noxious heat
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (2020-05-05)Capsaicin is the most abundant pungent molecule identifed in red chili peppers, and it is widely used for food favoring, in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and several other ... -
Eugenol and other vanilloids hamper caenorhabditis elegans response to noxious heat
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (Springer, 2020-10-29)Eugenol, a known vanilloid, was frequently used in dentistry as a local analgesic in addition, antibacterial and neuroprotective effects were also reported. Eugenol, capsaicin and many vanilloids are interacting with the transient receptor potential ... -
Proteomics reveals long-term alterations in signaling and metabolic pathways following both myocardial infarction and chemically induced denervation
Ben Salem, Jennifer; Iacovoni, Jason S.; Calise, Denis; Arvanitis, Dina N.; Beaudry, Francis (Elsevier, 2022-06-18)Myocardial infraction (MI) is the principal risk factor for the onset of heart failure (HF). Investigations regarding the physiopathology of MI progression to HF have revealed the concerted engagement of other tissues, such as the autonomic nervous ... -
Resiniferatoxin hampers the nocifensive response of Caenorhabditis elegans to noxious heat, and pathway analysis revealed that the Wnt signaling pathway is involved
Ben Salem, Jennifer; Nkambeu, Bruno; Arvanitis, Dina N.; Beaudry, Francis (Springer, 2021-10-25)Resiniferatoxin (RTX) is a metabolite extracted from Euphorbia resinifera. RTX is a potent capsaicin analog with specific biological activities resulting from its agonist activity with the transient receptor potential channel vanilloid subfamily member ... -
Rôle du TRPV1 dans la régulation cardio-protectrices des voies de signalisation locale et distale
Ben Salem, Jennifer (2023-06-15)L'insuffisance cardiaque (IC) est l'une des principales causes de décès dans le monde. Les maladies cardiovasculaires sont devenues une préoccupation majeure de santé publique et le resteront probablement à l'avenir avec le vieillissement de la ...