Parcourir Faculté de médecine vétérinaire par auteur·e "Jacques, Mario"
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Actinobacillus pleuropneumoniae (App) culture supernatant antiviral effect against porcine reproductive and respiratory syndrome virus (PRRSV) occurs prior to the viral genome replication and transcription through actin depolymerization
Hernandez Reyes, Yenney; Provost, Chantale; Kist Traesel, Carolina; Jacques, Mario; Gagnon, Carl A. (Microbiology Society, 2018-01-02)PURPOSE: Recently, the strong antiviral activity of an Actinobacillus pleuropneumoniae (App) culture supernatant against porcine reproductive and respiratory syndrome virus (PRRSV) was discovered. Following this finding, the objective of the present ... -
Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication
Ferreira Barbosa, Jérémy A.; Labrie, Josée; Beaudry, Francis; Gagnon, Carl A.; Jacques, Mario (2015-12)Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available. We recently ... -
Actinobacillus pleuropneumoniae Possesses an Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus
Lévesque, Cynthia; Provost, Chantale; Labrie, Josée; Hernandez Reyes, Yenney; Burciaga Nava, Jorge A.; Gagnon, Carl A.; Jacques, Mario (2014-05)Pigs are often colonized by more than one bacterial and/or viral species during respiratory tract infections. This phenomenon is known as the porcine respiratory disease complex (PRDC). Actinobacillus pleuropneumoniae (App) and porcine reproductive ... -
Effect of deoxynivalenol (DON) mycotoxin on in vivo and in vitro porcine circovirus type 2 infections
Savard, Christian; Provost, Chantale; Alvarez, Fernando; Pinilla, Vicente; Music, Nedzad; Jacques, Mario; Gagnon, Carl A.; Chorfi, Younès (2015-04)Deoxynivalenol (DON) is a mycotoxin produced by Fusarium spp and is a common contaminant of grains in North America. Among farm animals, swine are the most susceptible to DON because it markedly reduces feed intake and decreases weight gain. Porcine ... -
Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line
Provost, Chantale; Jia, Jian Jun; Music, Nedzad; Lévesque, Cynthia; Lebel, Marie-Ève; Del Castillo, Jérôme; Jacques, Mario; Gagnon, Carl A. (2012-11)Background Airborne transmitted pathogens, such as porcine reproductive and respiratory syndrome virus (PRRSV), need to interact with host cells of the respiratory tract in order to be able to enter and disseminate in the host organism. Pulmonary ... -
Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells
Hathroubi, Skander; Beaudry, Francis; Provost, Chantale; Martelet, Léa; Segura, Mariela; Gagnon, Carl A.; Jacques, Mario (SAGE, 2016-05-25)Actinobacillus pleuropneumoniae (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on both biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined the role of APP ... -
Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells
Hathroubi, Skander; Beaudry, Francis; Provost, Chantale; Martelet, Léa; Segura, Mariela; Gagnon, Carl A.; Jacques, Mario (2016-05-25)Actinobacillus pleuropneumoniae (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined the role of APP biofilm in ... -
Impact of Nutrient Restriction on the Structure of Listeria monocytogenes Biofilm Grown in a Microfluidic System
Cherifi, Tamazight; Jacques, Mario; Quessy, Sylvain; Fravalo, Philippe (2017-05-17)Biofilm formation by the pathogen Listeria monocytogenes is a major concern in food industries. The aim of this work was to elucidate the effect of nutrient limitation on both biofilm architecture and on the viability of the bacteria in ... -
Investigation of the species origin of the St. Jude porcine lung epithelial cell line (SJPL) made available to researchers
Silversides, David W.; Music, Nedzad; Jacques, Mario; Webby, Richard; Gagnon, Carl A. (2010-05) -
Persistence of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in bacterial biofilms
Jacques, Mario; Grenier, Daniel; Labrie, Josée; Provost, Chantale; Gagnon, Carl A. (2015)The aim of this pilot project was to investigate association of viruses with bacterial biofilms. Our preliminary data indicate that important viral pathogens of swine, namely, porcine reproductive and respiratory syndrome virus and porcine circovirus ... -
Untargeted and targeted metabolomics reveal that adenosine nucleotides released in Actinobacillus pleuropneumoniae supernatant inhibit porcine reproductive and respiratory syndrome virus replication
Salmin, Abdulrahman Fuad; Pesant, Marie-Jeanne; Burgher Pulgaron, Yaima; Provost, Chantale; Labrie, Josée; Jacques, Mario; Gagnon, Carl A.; Beaudry, Francis (Elsevier, 2022-02-18)Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most devastating viruses in the swine industry and causes major economic losses. To date, there has not been an effective antiviral treatment for the disease. We have shown in ...