Ion homeostasis in rhythmogenesis : the interplay between neurons and astroglia
dc.contributor.author | Kadala, Aklesso | |
dc.contributor.author | Verdier, Dorly | |
dc.contributor.author | Morquette, Philippe | |
dc.contributor.author | Kolta, Arlette | |
dc.date.accessioned | 2018-01-19T14:25:45Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2018-01-19T14:25:45Z | |
dc.date.issued | 2015-09 | |
dc.identifier.uri | http://hdl.handle.net/1866/19736 | |
dc.subject | Astrocytes | fr |
dc.subject | Rhythmogenesis | fr |
dc.subject | Homeostasis | fr |
dc.subject | Calcium | fr |
dc.subject | Potassium | fr |
dc.title | Ion homeostasis in rhythmogenesis : the interplay between neurons and astroglia | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine dentaire | fr |
UdeM.statut | Professeur(e) / Professor | fr |
dc.identifier.doi | 10.1152/physiol.00023.2014 | |
dcterms.abstract | Proper function of all excitable cells depends on ion homeostasis. Nowhere is this more critical than in the brain where the extracellular concentration of some ions determines neurons' firing pattern and ability to encode information. Several neuronal functions depend on the ability of neurons to change their firing pattern to a rhythmic bursting pattern, whereas, in some circuits, rhythmic firing is, on the contrary, associated to pathologies like epilepsy or Parkinson's disease. In this review, we focus on the four main ions known to fluctuate during rhythmic firing: calcium, potassium, sodium, and chloride. We discuss the synergistic interactions between these elements to promote an oscillatory activity. We also review evidence supporting an important role for astrocytes in the homeostasis of each of these ions and describe mechanisms by which astrocytes may regulate neuronal firing by altering their extracellular concentrations. A particular emphasis is put on the mechanisms underlying rhythmogenesis in the circuit forming the central pattern generator (CPG) for mastication and other CPG systems. Finally, we discuss how an impairment in the ability of glial cells to maintain such homeostasis may result in pathologies like epilepsy and Parkinson's disease. | fr |
dcterms.isPartOf | urn:ISSN:1548-9221 | |
dcterms.isPartOf | urn:ISSN:1548-9213 | |
dcterms.language | eng | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Physiology (Bethesda) | |
oaire.citationVolume | 30 | |
oaire.citationIssue | 5 | |
oaire.citationStartPage | 371 | |
oaire.citationEndPage | 388 |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.