Browsing Faculté de médecine vétérinaire – Travaux et publications by Author "Santamaria, Raphaël"
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In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry
Santamaria, Raphaël; Pailleux, Floriane; Beaudry, Francis (2014-12-01)Ketamine is widely used in medicine in combination with several benzodiazepines including midazolam. The objectives of this study were to develop a novel HPLC-MS/SRM method capable of quantifying ketamine and norketamine using an isotopic dilution ...