Browsing Titles index "Neurochemical research"
Now showing items 1-9 of 9
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Anandamide modulates thermal avoidance in caenorhabditis elegans through vanilloid and cannabinoid receptor interplay
(Springer, 2024-03-27)Understanding the endocannabinoid system in C. elegans may offer insights into basic biological processes and potential therapeutic targets for managing pain and inflammation in human. It is well established that anandamide modulates pain perception ... -
Antinociceptive activity of vanilloids in caenorhabditis elegans is mediated by the desensitization of the TRPV channel OCR-2 and specific signal transduction pathways
(Springer, 2023-02-03)Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged treatment with vanilloids triggered the desensitization of TRPV1, leading to analgesic or antinociceptive ... -
Cannabidiol and tetrahydrocannabinol antinociceptive activity is mediated by distinct receptors in caenorhabditis elegans
(Springer, 2023-11-22)Cannabis has gained popularity in recent years as a substitute treatment for pain following the risks of typical treatments uncovered by the opioid crisis. The active ingredients frequently associated with pain-relieving effects are the phytocannabinoids ... -
Capsaicin and Its analogues impede nocifensive response of caenorhabditis elegans to noxious heat
(2020-05-05)Capsaicin is the most abundant pungent molecule identifed in red chili peppers, and it is widely used for food favoring, in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and several other ... -
Eugenol and other vanilloids hamper caenorhabditis elegans response to noxious heat
(Springer, 2020-10-29)Eugenol, a known vanilloid, was frequently used in dentistry as a local analgesic in addition, antibacterial and neuroprotective effects were also reported. Eugenol, capsaicin and many vanilloids are interacting with the transient receptor potential ... -
Impaired EAT-4 vesicular glutamate transporter leads to defective nocifensive response of caenorhabditis elegans to noxious heat
(Springer, 2019-04-26)In mammals, glutamate is an important excitatory neurotransmitter. Glutamate and glutamate receptors are found in areas specifically involved in pain sensation, transmission and transduction such as peripheral nervous system, spinal cord and brain. ... -
Proteomics reveals long-term alterations in signaling and metabolic pathways following both myocardial infarction and chemically induced denervation
(Elsevier, 2022-06-18)Myocardial infraction (MI) is the principal risk factor for the onset of heart failure (HF). Investigations regarding the physiopathology of MI progression to HF have revealed the concerted engagement of other tissues, such as the autonomic nervous ... -
Resiniferatoxin hampers the nocifensive response of Caenorhabditis elegans to noxious heat, and pathway analysis revealed that the Wnt signaling pathway is involved
(Springer, 2021-10-25)Resiniferatoxin (RTX) is a metabolite extracted from Euphorbia resinifera. RTX is a potent capsaicin analog with specific biological activities resulting from its agonist activity with the transient receptor potential channel vanilloid subfamily member ... -
Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions
(2015-11-01)Substance P (SP) play a central role in nociceptive transmission and it is an agonist of the Neurokinin-1 receptor located in the lamina I of the spinal cord. SP is a major proteolytic product of the protachykinin-1 primarily synthesized in neurons. ...