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Lessons on brain edema in HE : from cellular to animal models and clinical studies
(Springer, 2023-08-22)
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations ...
The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
(American Association for the Advancement of Science, 2015-12-16)
Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ
transplant recipients. However, mechanisms of immunization to apoptotic components remain largely ...
GWAS of hematuria
GWAS of non-genitourinary hematuriaGWAS reveals hematuria mechanisms
(American Society of Nephrology, 2022-05-01)
Background and objectives
Glomerular hematuria has varied causes but can have a genetic basis, including Alport syndrome and IgA nephropathy.
Design, setting, participants, & measurements
We used summary statistics ...
Adhesion and transcellular migration of neutrophils and B lymphocytes on fibroblasts
(2009)
During tissue inflammation, infiltrated leukocytes may have physical contacts with fibroblasts. We observed that neutrophils and B lymphocytes adhered in a larger proportion than T cells on cultured fibroblasts. Microscopy ...
Yeast RNase III triggers polyadenylation-independent transcription termination
(2009)
Transcription termination of messenger RNA (mRNA) is normally achieved by polyadenylation followed by Rat1p-dependent 5'-3' exoribonuleolytic degradation of the downstream transcript. Here we show that the yeast ortholog ...
Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
(Springer Nature, 2022-02-11)
Apoptotic exosome-like vesicles (ApoExos) are a novel type of extracellular vesicle that contribute to the propagation of inflammation at sites of vascular injury when released by dying cells. ApoExos are characterized by ...
Letters to the Editor: Correspondence re R. Lapointe et al., CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells. Cancer Res 2003;63:2836–43.
(HighWire Press (American Association for Cancer Research), 2004-06-01)
CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells
(HighWire Press (American Association for Cancer Research), 2003-06-01)
Although they are considered as antigen presenting cells (APC), the role of antigen-unspecific B-lymphocytes in antigen presentation and T lymphocyte stimulation remains controversial. In this paper, we tested the capacity ...
Melanosomal targeting sequences from gp100 are essential for MHC class II-restricted endogenous epitope presentation and mobilization to endosomal compartments
(HighWire Press (American Association for Cancer Research), 2006-02-15)
CD4+ T lymphocytes play an important role in CD8+ T cell-mediated responses against tumors. Considering that about 20% of melanomas express major histocompatibility complex (MHC) class II, it is plausible that concomitant ...
Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease
(Wiley, 2024-04-29)
Hepatic encephalopathy (HE) is defined as decline in neurological function during
chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of
fibrosis/cirrhosis and has also been documented ...