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The Portacaval‐shunted rat : a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?
(Wiley, 1997-04)
Portacaval anastomosis (PCA) is a surgical procedure whereby blood from the portal vein is shunted into the inferior vena cava. PCA in the rat results in a significant increase (from 0.77 ± 0.26 to 3.51 ± 0.37 g of ...
Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis
(Wiley, 2017-06-30)
Background & Aims
Recent studies suggest that heparins reduce liver fibrosis and the risk of decompensation of liver disease. Here, we evaluated the effects of enoxaparin in several experimental models of advanced ...
2021 ISHEN guidelines on animal models of hepatic encephalopathy
(Wiley, 2021-04-01)
This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models ...
Hepatic encephalopathy : novel insights into classification, pathophysiology and therapy
(Elsevier, 2020-10-21)
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild ...
A simplified approach to extravascular lung water assessment using point-of-care ultrasound in patients with end-stage chronic renal failure undergoing hemodialysis
(Karger publishers, 2017-12-07)
Background: Fluid overload leading to pulmonary congestion is an important issue in patients undergoing hemodialysis. This study aimed to determine if a simplified method of extravascular lung water assessment using ...
Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma
(Nature Research, 2020-07-20)
The mechanisms generating cancer-initiating mutations are not well understood. Sonic hedgehog (SHH) pathway activation is frequent in medulloblastoma (MB), with PTCH1 mutations being a common initiating event. Here we ...
Autophagy, tissue repair, and fibrosis: a delicate balance
(Elsevier, 2021-01-14)
Tissue repair and fibrosis, an abnormal form of repair, occur in most human organs in response to injury or inflammation. Fibroblasts play a major role in the normal repair process by differentiating into myofibroblasts ...
Progressive resistance training prevents loss of muscle mass and strength in bile duct‐ligated rats
(Wiley, 2018-11-05)
BACKGROUND: Loss of muscle mass and strength is common in cirrhosis and increases
the risk of hyperammonaemia and hepatic encephalopathy. Resistance training
optimizes muscle mass and strength in several ...
Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats
(Lippincott, Williams & Wilkins, 2020-07-06)
BACKGROUND
Multiorgan failure is a consequence of severe ischemia-reperfusion injury after traumatic hemorrhagic shock (HS), a major cause of mortality in trauma patients. Circulating uric acid (UA), released from cell ...
Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure
(Wiley, 2017-01-19)
Background/Aim
Acetaminophen (APAP)-induced Acute Liver Failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Hypothesis: Serum Liver-type Fatty Acid Binding Protein (FABP1) ...