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HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing
(2010)
HIV upregulates cell-surface expression of specific ligands for the activating NKG2D receptor, including ULBP-1, -2, -3, but not MICA or MICB, in infected cells both in vitro and in vivo. However, the viral factor(s) ...
Utilization of biodiesel-derived glycerol or xylose for increased growth and lipid production by indigenous microalgae
(Bioresource Technology, 2014)
The use of industrial wastes rich in mineral nutrients and carbon sources to increase the final microalgal biomass and lipid yield at a low cost is an important strategy to make algal biofuel technology viable. Using strains ...
Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes
(Public Library of Science, 2017-05-01)
Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they
promote the development of type 2 diabetes is ...
Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer
(Frontiers media, 2013-01-13)
A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the ...
HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest
(2010)
HIV-1 viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by a mechanism involving the activation of the DNA damage sensor ATR. We and others recently showed that Vpr performs this function by subverting ...
Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment
(2010)
The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports proposed beta-TrCP-dependent proteasomal ...
Amino acids substitutions in σ1 and μ1 outer capsid proteins of a Vero cell-adapted mammalian orthoreovirus are required for optimal virus binding and disassembly
(Elsevier, 2015-01-01)
In a recent study, the serotype 3 Dearing strain of mammalian orthoreovirus was adapted to Vero cells; cells that exhibit a limited ability to support the early steps of reovirus uncoating and are unable to produce interferon ...
Functional characterization of CaVα2δ mutations associated with sudden cardiac death
(Elsevier, 2015-01-30)
L-type Ca(2+) channels play a critical role in cardiac rhythmicity. These ion channels are oligomeric complexes formed by the pore-forming CaVα1 with the auxiliary CaVβ and CaVα2δ subunits. CaVα2δ increases the peak current ...
IL23R (Interleukin 23 Receptor) variants protective against inflammatory bowel diseases (IBD) display loss of functiondue to impaired protein stability and intracellular trafficking
(Elsevier, 2016)
Genome-wide association studies as well as murine models
have shown that the interleukin 23 receptor (IL23R) pathway
plays a pivotal role in chronic inflammatory diseases such as
Crohn disease (CD), ulcerative colitis, ...
Addition of exogenous polypeptides on the mammalian reovirus outer capsid using reverse genetics
(Elsevier, 2012-02)
Addition of exogenous peptide sequences on viral capsids is a powerful approach to study the
process of viral infection or to retarget viruses toward defined cell types. Until recently, it was
not possible to manipulate ...