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Further characterization and determination of the single amino acid change in the tsI138 reovirus thermosensitive mutant
(NRC Research Press, 2012-05)
Many temperature-sensitive mutants have been isolated in early studies of mammalian reovirus. However, the bio- logical properties and nature of the genetic alterations remain incompletely explored for most of these mutants. ...
A single amino acid substitution in the mRNA capping enzyme λ2 of a mammalian orthoreovirus mutant increases interferon sensitivity
(Elsevier, 2015-09-01)
In the last few years, the development of a plasmid-based reverse genetics system for mammalian reovirus has allowed the production and characterization of mutant viruses. This could be especially significant in the ...
Addition of exogenous polypeptides on the mammalian reovirus outer capsid using reverse genetics
(Elsevier, 2012-02)
Addition of exogenous peptide sequences on viral capsids is a powerful approach to study the
process of viral infection or to retarget viruses toward defined cell types. Until recently, it was
not possible to manipulate ...
La génétique inverse dans l'étude des réovirus: Progrès, obstacles et développements futurs
(John Libbey Eurotext, 2011-01)
En génétique dite « classique », l’examen d’un phénotype conduit à l’étude des gènes impliqués dans son obtention. La génétique inverse est une méthode expérimentale très puissante dans laquelle, au contraire, le matériel ...
Amino acid substitutions in σ1 and μ1 outer capsid proteins are selected during mammalian reovirus adaptation to Vero cells
(Elsevier, 2013-09)
Establishment of viral persistence in cell culture has previously led to the selection of mammalian reovirus mutants, although very few of those have been characterized in details. In the present study, reovirus was adapted ...
Amino acids substitutions in σ1 and μ1 outer capsid proteins of a Vero cell-adapted mammalian orthoreovirus are required for optimal virus binding and disassembly
(Elsevier, 2015-01-01)
In a recent study, the serotype 3 Dearing strain of mammalian orthoreovirus was adapted to Vero cells; cells that exhibit a limited ability to support the early steps of reovirus uncoating and are unable to produce interferon ...
Transient high level mammalian reovirus replication in a bat epithelial cell line occurs without cytopathic effect
(Elsevier, 2013-05-01)
Mammalian reoviruses exhibit a large host range and infected cells are generally killed;
however, most studies examined only a few cell types and host species, and are probably not
representative of all possible interactions ...