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Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes
(Public Library of Science, 2017-05-01)
Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they
promote the development of type 2 diabetes is ...
Effect of calcium-modulating cyclophilin ligand on human immunodeficiency virus type 1 particle release and cell surface expression of Tetherin
(2009)
The HIV-1 accessory protein Vpu enhances virus particle release by counteracting a host factor that retains virions at the cell surface of infected cells. It was recently demonstrated that cellular protein BST2/CD317/Tetherin ...
HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing
(2010)
HIV upregulates cell-surface expression of specific ligands for the activating NKG2D receptor, including ULBP-1, -2, -3, but not MICA or MICB, in infected cells both in vitro and in vivo. However, the viral factor(s) ...
Longitudinal changes in HIV-specific IFN-? secretion in subjects who received Remune™ vaccination prior to treatment interruption
(2006)
BACKGROUND:Despite the benefits of highly active antitretroviral therapy (HAART) for suppressing viral replication in HIV infection, virus persists and rebounds during treatment interruption (TI). This study explored whether ...
Telehealth for people who inject drugs : An acceptable method of treatment but challenging to access
(Routledge, 2022-02-08)
Background:
While telemedicine is seen as an emerging practice that will outlast the COVID-19 pandemic, it
can reduce health services for those with limited internet and technological devices access or
sufficient li ...
Utilization of biodiesel-derived glycerol or xylose for increased growth and lipid production by indigenous microalgae
(Bioresource Technology, 2014)
The use of industrial wastes rich in mineral nutrients and carbon sources to increase the final microalgal biomass and lipid yield at a low cost is an important strategy to make algal biofuel technology viable. Using strains ...
Bisphosphoglycerate mutase deficiency protects against cerebral malaria and severe malaria-induced anemia
(Cell Press, 2020-09-22)
The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, ...
Restoring T cell homeostasis after allogeneic stem cell transplantation; principal limitations and future challenges
(Frontiers Media, 2018-06-18)
For several leukemia patients, allogeneic stem cell transplantation (allogeneic-SCT) is
the unique therapeutic modality that could potentially cure their disease. Despite significant progress made in clinical management ...
The NOD mouse beyond autoimmune diabetes
(Frontiers Media, 2022-04-29)
Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the
pathophysiology of this disease shares many similarities with human type 1 diabetes.
Since its generation in 1980, the NOD mouse, derived ...
Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer
(Frontiers media, 2013-01-13)
A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the ...