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Ammonia toxicity: from head to toe?
(Springer, 2016-12)
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily ...
The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis
(Springer, 2016-12)
Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase ...
Implication of hypotension in the pathogenesis of cognitive impairment and brain injury in chronic liver disease
(Springer, 2023-01-13)
The incidence of chronic liver disease is on the rise. One of the primary causes of hospital admissions for patients with cirrhosis is hepatic encephalopathy (HE), a debilitating neurological complication. HE is defined ...
Mathematical models and hepatology; oil and vinegar?
(Elsevier, 2016-01)
Mathematical models are increasingly being used in medicine to study physiological, pathophysiological and therapeutic pathways [1–3]. In hepatology, mathematical abstractions have been beneficial to predict the viral load ...
Targeting the muscle for the treatment and prevention of hepatic encephalopathy
(Elsevier, 2016-08)
Muscle mass loss or sarcopenia is a principle component of malnutrition which prevails in 65–90% of patients with end-stage liver disease [1]. Intuitively, the roots of malnutrition play a precipitating role in muscle ...
Ammonia : this is not the end but rather the end of the beginning
(Elsevier, 2018-04)
Hepatic encephalopathy (HE) represents a wide spectrum of neurological or neuropsychological symptoms caused by liver disease and/or portosystemic shunts. The major role of hyperammonemia in association with systemic ...
175 years of bilirubin testing : ready for point-of-care?
(Wiley, 2023-04-10)
Bilirubin was first detected in blood in 1847 and since then has become one of
the most widely used biomarkers for liver disease. Clinical routine bilirubin
testing is performed at the hospital laboratory, and the gold ...
Lessons on brain edema in HE : from cellular to animal models and clinical studies
(Springer, 2023-08-22)
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations ...
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
(2014)
The pathogenesis of brain edema in patients with chronic liver disease (CLD) and minimal hepatic encephalopathy (HE) remains undefined. This study evaluated the role of brain lactate, glutamine and organic osmolytes, ...