Browsing Faculté de médecine by Affiliation "Université de Montréal. Faculté de médecine"
Now showing items 1-20 of 62
-
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH
(2005)Hyperammonemia is a key factor in the pathogenesis of hepatic encephalopathy (HE) as well as other metabolic encephalopathies, such as those associated with inherited disorders of urea cycle enzymes and in Reye's syndrome. Acute HE results in increased ... -
Ammonia: more than a neurotoxin?
(2014) -
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure
(2007-12)We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP). This was independent of changes in arterial ammonia, ... -
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats
(2011)The pathogenesis of hepatic encephalopathy is multifactorial, involving gut-derived toxins such as ammonia, which has been demonstrated to induce oxidative stress. Therefore, a primary hepatic encephalopathy treatment target is reducing ammonia production ... -
Bibliothèques spécialisées et publiques : imaginer un partenariat au service des aînés du Québec
(Institut universitaire de gériatrie de Montréal, 2010-11-04)La bibliothèque de l’Institut universitaire de gériatrie de Montréal (IUGM) a réalisé une étude de faisabilité sur la possibilité d’établir un partenariat avec les bibliothèques publiques du Québec afin de diffuser de l’information de qualité aux ... -
Brain edema in acute liver failure and chronic liver disease: Similarities and differences
(2013)Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that typically develops as a result of acute liver failure or chronic liver disease. Brain edema is a common feature associated with HE. In acute liver failure, brain edema contributes ... -
Co-morbidity between gambling problems and depressive symptoms: A longitudinal perspective of risk and protective factors
(Springer Verlag, 2016)In both adolescents and adults, gambling problems and depressive symptoms co-occur and share some common risk factors (e.g., impulsivity and socio-family risk). However, little is known about (1) the developmental course of the co-morbidity of these ... -
Comorbid development of disruptive behaviors from age 1½ to 5 years in a population birth-cohort and association with school adjustment in first grade
Comorbidity of Disruptive Behaviors from age 1½ to 5 years
(Springer Verlag, 2016-05)Comorbidity is frequent among disruptive behaviors (DB) and leads to mental health problems during adolescence and adulthood. However, the early developmental origins of this comorbidity have so far received little attention. This study investigated ... -
Contractile response of femoral arteries in pigs with acute liver failure
(2004)BACKGROUND: Acute liver failure (ALF) is characterized haemodynamically by a progressive hyperdynamic circulation. The pathophysiological mechanism is unknown, but impaired contractility of vascular smooth muscle may play an important role. The aim of ... -
Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure
(1997-07)It has been suggested that reduced astrocytic uptake of neuronally released glutamate contributes to the pathogenesis of hepatic encephalopathy in acute liver failure. In order to further address this issue, the recently cloned and sequenced astrocytic ... -
Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel
(Cell press, 2021-06-04)Untargeted metabolomics is used to refine the development of biomarkers for the diagnosis of cardiovascu-lar disease. Myocardial infarction (MI) has major individual and societal consequences for patients, whoremain at high risk of secondary events, ... -
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure
(2006-06)BACKGROUND/AIMS: It has been proposed that, in acute liver failure, skeletal muscle adapts to become the principle organ responsible for removal of blood-borne ammonia by increasing glutamine synthesis, a reaction that is catalyzed by the cytosolic ... -
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
(2006-01)BACKGROUND: Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin dialysis in ALF with use of the ... -
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle
(1999)The effects of chronic liver insufficiency resulting from end-to-side portacaval anastomosis (PCA) on glutamine synthetase (GS) activities, protein and gene expression were studied in brain, liver and skeletal muscle of male adult rats. Four weeks ... -
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study
(2003)Mild hypothermia has a protective effect on brain edema and encephalopathy in both experimental and human acute liver failure. The goals of the present study were to examine the effects of mild hypothermia (35°C) on brain metabolic pathways using ... -
Emerging applications of extra-cardiac ultrasound in critically ill cardiac patients
(Elsevier, 2022-12-10)Point-of-care ultrasound has evolved as an invaluable diagnostic modality and procedural guidance tool in the care of critically ill cardiac patients. Beyond focused cardiac ultrasound, additional extracardiac ultrasound modalities may provide important ... -
fNIRS-EEG study of focal interictal epileptiform discharges
(Elsevier, 2014-03)Functional near-infrared spectroscopy (fNIRS) acquired with electroencephalography (EEG) is a relatively new non-invasive neuroimaging technique with potential for long term monitoring of the epileptic brain. Simultaneous EEG-fNIRS recording allows the ... -
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by {beta}-catenin signaling
(Public Library of Science, 2008)BACKGROUND: The role of ss-catenin signaling in mesodermal lineage formation and differentiation has been elusive. METHODOLOGY: To define the role of ss-catenin signaling in these processes, we used a Dermo1(Twist2)(Cre/+) line to target a floxed ... -
Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes
(Oxford University Press, 2008)Proteolytic processing of the CUX1 transcription factor generates an isoform, p110 that accelerates entry into S phase. To identify targets of p110 CUX1 that are involved in cell cycle progression, we performed genome-wide location analysis using a ...