Browsing Faculté de médecine by Affiliation "Université de Montréal. Faculté de médecine"
Now showing items 21-40 of 64
-
Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes
(Oxford University Press, 2008)Proteolytic processing of the CUX1 transcription factor generates an isoform, p110 that accelerates entry into S phase. To identify targets of p110 CUX1 that are involved in cell cycle progression, we performed genome-wide location analysis using a ... -
Hemodynamic changes during posterior epilepsies: an eeg-fnirs study
(Elsevier, 2014)Posterior epilepsies are relatively rare, mainly suspected clinically by the presence of visual auras. Functional near-infrared spectroscopy (fNIRS) is an emerging non-invasive imaging technique that has the potential to monitor hemodynamic changes ... -
High postoperative portal venous flow pulsatility indicates right ventricular dysfunction and predicts complications in cardiac surgery patients
(Elsevier, 2018-11-28)Background Right ventricular failure after cardiac surgery is associated with morbidity and mortality. Right ventricular dysfunction results in hepatic venous congestion, which impacts the portal circulation. We aimed to determine whether an increased ... -
Hypothermia in acute liver failure
(2004)The development of encephalopathy in patients with acute liver injury defines the occurrence of liver failure. The encephalopathy of acute liver failure is characterized by brain edema which manifests clinically as increased intracranial pressure. ... -
Identifying the direct effects of ammonia on the brain
(2009-03)Elevated concentrations of ammonia in the brain as a result of hyperammonemia leads to cerebral dysfunction involving a spectrum of neuropsychiatric and neurological symptoms (impaired memory, shortened attention span, sleep-wake inversions, brain ... -
Increase brain lactate in hepatic encephalopathy: Cause or consequence?
(2010-11)Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome which develops as a result of liver failure or disease. Increased concentrations of brain lactate (microdialysate, cerebrospinal fluid, tissue) are commonly measured in patients with ... -
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
(2014)The pathogenesis of brain edema in patients with chronic liver disease (CLD) and minimal hepatic encephalopathy (HE) remains undefined. This study evaluated the role of brain lactate, glutamine and organic osmolytes, including myo-inositol and taurine, ... -
Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis
(2002)Increased binding sites for "peripheral-type" benzodiazepine receptor (PTBR) ligands have been described in a wide range of neurological disorders including both human and experimental epilepsy. This study was undertaken to assess PTBR expression in ... -
Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?
(2002)Glutamatergic dysfunction has been suggested to play an important role in the pathogenesis of hepatic encephalopathy (HE) in acute liver failure (ALF). Increased extracellular brain glutamate concentrations have consistently been described in different ... -
Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis
(2003)Induction of cyclooxygenase-2 (COX-2) has been described in a wide range of neurological diseases including animal models of epilepsy. The present study was undertaken to assess COX-2 expression in hippocampal biopsies from patients with therapy-refractive ... -
The intergenerational association between parents' problem gambling and impulsivity-hyperactivity/inattention behaviors in children
Parents’ problem gambling and children’s IH/I behaviors
(Springer Verlag, 2017-11-04)Despite the well-established association between problem gambling and ADHD core categories of impulsivity-hyperactivity and inattention, the link between parents’ problem gambling and impulsivity-hyperactivity/inattention (IH/I) behaviors in children ... -
Keeping cool in acute liver failure: rationale for the use of mild hypothermia
(2005)Encephalopathy, brain edema and intracranial hypertension are neurological complications responsible for substantial morbidity/mortality in patients with acute liver failure (ALF), where, aside from liver transplantation, there is currently a paucity ... -
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure
(2009-07)Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic ... -
L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action
(1998-06)Strategies aimed at the lowering of blood ammonia remain the treatment of choice in portal-systemic encephalopathy (PSE). L-ornithine-L-aspartate (OA) has recently been shown to be effective in the prevention of ammonia-precipitated coma in humans with ... -
Le libre accès pour les bibliothèques de la santé : des ressources à découvrir
(Institut universitaire de gériatrie de Montréal ; Hôpital général juif (Montréal, Québec), 2009-02-05)Cette présentation s’adresse aux spécialistes de l’information du milieu de la santé et aborde les points suivants : 1. Le monde du « libre accès » : définitions et statistiques; 2. Utiliser les ressources en libre accès; 3. Publier en libre accès ... -
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide
(2005-12)Chronic liver failure leads to hyperammonemia and consequently increased brain ammonia concentrations, resulting in hepatic encephalopathy. When the liver fails to regulate ammonia concentrations, the brain, devoid of a urea cycle, relies solely on the ... -
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure
(2001)There is increasing evidence that central noradrenaline (NA) transport mechanisms are implicated in the central nervous system complications of acute liver failure. In order to assess this possibility, binding sites for the high affinity NA transporter ... -
Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction
(1999)BACKGROUND & AIMS: Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases ... -
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects
(2002-12)Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial ...