Liens externes
  • Directories
  • Faculties
  • Libraries
  • Campus maps
  • Sites A to Z
  • My UdeM
    • Mon portail UdeM
    • My email
    • StudiUM
Dessin du pavillon Roger Gaudry/Sketch of Roger Gaudry Building
University Home pageUniversity Home pageUniversity Home page
Papyrus : Institutional Repository
Papyrus
Institutional Repository
Papyrus
    • français
    • English
  • English 
    • français
    • English
  • Login
  • English 
    • français
    • English
  • Login
View Item 
  •   Home
  • Faculté de médecine vétérinaire
  • Faculté de médecine vétérinaire – Travaux et publications
  • View Item
  •   Home
  • Faculté de médecine vétérinaire
  • Faculté de médecine vétérinaire – Travaux et publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

My Account

To submit an item or subscribe to email alerts.
Login
New user?

Browse

All of PapyrusCommunities and CollectionsTitlesIssue DatesAuthorsAdvisorsSubjectsDisciplinesAffiliationTitles indexThis CollectionTitlesIssue DatesAuthorsAdvisorsSubjectsDisciplinesAffiliationTitles index

Statistics

View Usage Statistics
Show metadata
Permalink: http://hdl.handle.net/1866/12205

Potential use of a recombinant replication-defective adenovirus vector carrying the C-terminal portion of the P97 adhesin protein as a vaccine against Mycoplasma hyopneumoniae in swine

Article [Accepted Manuscript]
Thumbnail
Okamba et al 2010.pdf (373.0Kb)
Is part of
Vaccine ; vol. 28, no. 30, pp. 4802-4809.
2010-07
Author(s)
Okamba, Faust René
Arella, Maximilien
Music, Nedzad
Jia, Jian Jun
Gottschalk, Marcelo
Gagnon, Carl A.
Affiliation
  • Université de Montréal. Faculté de médecine vétérinaire
Keywords
  • Mycoplasma hyopneumoniae
  • P97 adhesin
  • Replication-defective adenovirus
  • Vaccination
  • Porcine enzootic pneumonia
Abstract(s)
Mycoplasma hyopneumoniae causes severe economic losses to the swine industry worldwide and the prevention of its related disease, enzootic porcine pneumonia, remains a challenge. The P97 adhesin protein of M. hyopneumoniae should be a good candidate for the development of a subunit vaccine because antibodies produced against P97 could prevent the adhesion of the pathogen to the respiratory epithelial cells in vitro. In the present study, a P97 recombinant replication-defective adenovirus (rAdP97c) subunit vaccine efficiency was evaluated in pigs. The rAdP97c vaccine was found to induce both strong P97 specific humoral and cellular immune responses. The rAdP97c vaccinated pigs developed a lower amount of macroscopic lung lesions (18.5 ± 9.6%) compared to the unvaccinated and challenged animals (45.8 ± 11.5%). rAdP97c vaccine reduced significantly the severity of inflammatory response and the amount of M. hyopneumoniae in the respiratory tract. Furthermore, the average daily weight gain was slightly improved in the rAdP97c vaccinated pigs (0.672 ± 0.068 kg/day) compared to the unvaccinated and challenged animals (0.568 ± 0.104 kg/day). A bacterin-based commercial vaccine (Suvaxyn® MH-one) was more efficient to induce a protective immune response than rAdP97c even if it did not evoke a P97 specific immune response. These results suggest that immunodominant antigens other than P97 adhesin are also important in the induction of a protective immune response and should be taken into account in the future development of M. hyopneumoniae subunit vaccines.
Other location(s)
https://doi.org/10.1016/j.vaccine.2010.04.089
Collections
  • Faculté de médecine vétérinaire – Travaux et publications [85]

DSpace software [version 5.8 XMLUI], copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Certificat SSL / SSL Certificate
les bibliothéques/UdeM
  • Emergency
  • Private life
  • Careers
  • My email
  • StudiUM
  • iTunes U
  • Contact us
  • Facebook
  • YouTube
  • Twitter
  • University RSS
 

 


DSpace software [version 5.8 XMLUI], copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Certificat SSL / SSL Certificate
les bibliothéques/UdeM
  • Emergency
  • Private life
  • Careers
  • My email
  • StudiUM
  • iTunes U
  • Contact us
  • Facebook
  • YouTube
  • Twitter
  • University RSS