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dc.contributor.authorOkamba, Faust René
dc.contributor.authorArella, Maximilien
dc.contributor.authorMusic, Nedzad
dc.contributor.authorJia, Jian Jun
dc.contributor.authorGottschalk, Marcelo
dc.contributor.authorGagnon, Carl A.
dc.date.accessioned2015-07-14T16:33:49Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2015-07-14T16:33:49Z
dc.date.issued2010-07
dc.identifier.citationOkamba, F.R., Arella, M., Music, N., Jia, J.J., Gottschalk, M., Gagnon, C.A. (2010). Potential use of a recombinant replication-defective adenovirus vector carrying the C-terminal portion of the P97 adhesin protein as a vaccine against Mycoplasma hyopneumoniae in swine. Vaccine, 28(30), 4802-4809.fr
dc.identifier.urihttp://hdl.handle.net/1866/12205
dc.subjectMycoplasma hyopneumoniaefr
dc.subjectP97 adhesinfr
dc.subjectReplication-defective adenovirusfr
dc.subjectVaccinationfr
dc.subjectPorcine enzootic pneumoniafr
dc.titlePotential use of a recombinant replication-defective adenovirus vector carrying the C-terminal portion of the P97 adhesin protein as a vaccine against Mycoplasma hyopneumoniae in swine
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine vétérinairefr
UdeM.statutProfesseur(e) / Professorfr
dc.identifier.doi10.1016/j.vaccine.2010.04.089
dcterms.abstractMycoplasma hyopneumoniae causes severe economic losses to the swine industry worldwide and the prevention of its related disease, enzootic porcine pneumonia, remains a challenge. The P97 adhesin protein of M. hyopneumoniae should be a good candidate for the development of a subunit vaccine because antibodies produced against P97 could prevent the adhesion of the pathogen to the respiratory epithelial cells in vitro. In the present study, a P97 recombinant replication-defective adenovirus (rAdP97c) subunit vaccine efficiency was evaluated in pigs. The rAdP97c vaccine was found to induce both strong P97 specific humoral and cellular immune responses. The rAdP97c vaccinated pigs developed a lower amount of macroscopic lung lesions (18.5 ± 9.6%) compared to the unvaccinated and challenged animals (45.8 ± 11.5%). rAdP97c vaccine reduced significantly the severity of inflammatory response and the amount of M. hyopneumoniae in the respiratory tract. Furthermore, the average daily weight gain was slightly improved in the rAdP97c vaccinated pigs (0.672 ± 0.068 kg/day) compared to the unvaccinated and challenged animals (0.568 ± 0.104 kg/day). A bacterin-based commercial vaccine (Suvaxyn® MH-one) was more efficient to induce a protective immune response than rAdP97c even if it did not evoke a P97 specific immune response. These results suggest that immunodominant antigens other than P97 adhesin are also important in the induction of a protective immune response and should be taken into account in the future development of M. hyopneumoniae subunit vaccines.fr
dcterms.bibliographicCitationVaccine ; vol. 28, no 30
dcterms.isPartOfurn:ISSN:1873-2518
dcterms.isPartOfurn:ISSN:0264-410X
dcterms.languageengfr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscript


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