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The brain-derived neurotrophic factor prompts platelet aggregation and secretion
(American Society of Hematology, 2021-09-21)
Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in
neurons, and its release and signaling mechanisms have been extensively studied in the
central nervous system. Large quantities of BDNF ...
A meta-analysis of the effect of paper versus digital reading on reading comprehension in health professional education
(American Association of Colleges of Pharmacy, 2021-12-29)
Objective. Despite a rise in the use of digital education in health professional education (HPE), little is
known about the comparative effectiveness of paper-based reading and its digital alternative on reading
comprehension. ...
A randomized double-blind feasibility study comparing cetirizine and diphenhydramine in the prevention of paclitaxel-associated infusion-related reactions : the PREMED-F1 study
(Springer, 2022-01-08)
Purpose. Cetirizine is a less sedative alternative to diphenhydramine for the prevention
of infusion-related reactions (IRR) to paclitaxel. However, its use remains controversial. In this
study, we assessed feasibility ...
Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
Thrombocytopenia in acute coronary syndromes
(Taylor & Francis, 2018-10-22)
Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence ...
Antiplatelet therapy for atherothrombotic disease in 2022 : from population to patient-centered approaches
(Frontiers Media, 2022-01-28)
Antiplatelet agents, with aspirin and P2Y12 receptor antagonists as major key molecules, are currently the cornerstone of pharmacological treatment of atherothrombotic events including a variety of cardio- and cerebro-vascular ...
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults
(Frontiers Media, 2022-02-21)
The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated ...