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Effect of polymer architecture on Curcumin 1 encapsulation and release from PEGylated polymer nanoparticles: toward a drug delivery nano-platform to the CNS
(2015-10-01)
We developed a nanoparticles (NPs) library from poly(ethylene glycol)–poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat ...
Effect of Polymer Architecture on the Structural and Biophysical Properties of PEG-PLA Nanoparticles
(2015-05-01)
Polymers made of poly(ethylene glycol) chains grafted to poly(lactic acid) chains (PEG-g-PLA) were used to produce stealth drug nanocarriers. A library of comb-like PEG-g-PLA polymers with different PEG grafting densities ...
Preparedness for the next epidemic : health and political issues of an emerging paradigm
(Taylor & Francis, 2018-03-08)
‘Preparing for the next epidemic’ has been a recurrent theme in global
health in recent years. Starting with SARS, by way of the Avian influenza, and
intensifying after the 2013–2016 Ebola outbreak, the urgency of ...
Drug-loaded nanocarriers : passive targeting and crossing of biological barriers
(2012-12)
Poor bioavailability and poor pharmacokinetic characteristics are some of the leading causes of drug development failure. Therefore, poorly-soluble drugs, fragile proteins or nucleic acid products may benefit from their ...
Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
Thrombocytopenia in acute coronary syndromes
(Taylor & Francis, 2018-10-22)
Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence ...
Assessment of PEG on Polymeric Particles Surface, a Key Step in Drug Carrier Translation
(2014-07)
Injectable drug nanocarriers have greatly benefited in their clinical development from the addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The most studied and used polymer for this ...
De la mesure au sens de la mesure : l’économie scripturaire du sida et de son traitement en République centrafricaine (RCA)
(Société d'Anthropologie des Connaissances, 2016-06-30)
Pour donner sens à la mesure, il faut la rapporter à un système de valeurs qui en permet l’évaluation et le jugement. Voilà le parti pris théorique qui sous-tend cet article consacré aux pratiques d’écriture de la lutte ...
Mechanistic insights into the directed assembly of hydrogel blocks mediated by polyelectrolytes or microgels
(2017-04-18)
In this study, we report the directed assembly of hydrogel blocks mediated by
electrostatic interactions. We compared two different assembly mechanisms, one
mediated by microgel particles and another mediated ...
Tyrosine-based rivastigmine-loaded organogels in the treatmant of Alzheimer's disease
(2010-08)
Organogels can be prepared by immobilizing an organic phase into a threedimensional
network coming from the self-assembly of a low molecular weight gelator molecule. In this work, an injectable subcutaneous organogel ...
Understanding and diagnosing the potential for bias when using machine learning methods with doubly robust causal estimators
(SAGE, 2018-05-02)
Data-adaptive methods have been proposed to estimate nuisance parameters when using doubly robust semiparametric methods for estimating marginal causal effects. However, in the presence of near practical positivity violations, ...