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Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
(Elsevier, 2018-10-11)
We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile ...
Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
(American Chemical Society, 2018-01-29)
Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block ...
Non-covalent formulation of active principles with dendrimers: current state-of-the-art and prospects for further development
(Elsevier, 2017-09-06)
During the last three decades, dendrimers, nano-sized highly-branched fractal-like symmetrical macromolecules, have been intensively studied as promising candidates for application as drug-delivery carriers. Among other ...
Release kinetics from nano-inclusion-based and affinity-based hydrogels: A comparative study
(Elsevier, 2017-06-15)
In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different
compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholi ...
Quantification of peptides in human synovial fluid using liquid chromatography–tandem mass spectrometry
(Elsevier, 2018-04-06)
A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides ...
Platelet function in aging
(Frontiers Media, 2019-08-07)
Aging is associated with an increased incidence of cardiovascular disease and
thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus
formation, making them a key player in thrombotic disorders. ...
Formulation development and characterization of liquisolid tablets containing clozapine
(2015-02-27)
L’objectif de ce projet était de développer une formulation liquisolide (LS) de clozapine ayant des propriétés de dissolution améliorées et évaluer sa stabilité et ainsi que sa robustesse à la modification d’excipients. ...
Utilisation et développement de techniques pharmacocinétiques avancées afin d’améliorer le développement de molécules pharmaceutiques
(2015-02-27)
Malgré le progrès technologique et nos connaissances pharmaceutiques et médicales croissantes, le développement du médicament demeure un processus difficile, dispendieux, long et très risqué. Ce processus mérite d'être ...
Unraveling the correlations between conformation, lubrication, and chemical stability of bottlebrush polymers at interfaces
(American Chemical Society, 2017-09-29)
In the present study, we monitored the conformation and chemical stability of a hydrophilic bottlebrush (BB) polymer in pure water and buffered saline solutions. We correlated these parameters to lubricating and wear ...
Polymeric micelles as versatile carriers for drugs and nucleic acids
(2010-01-07)
Le cancer est la principale cause de mortalité au Canada. Les taxanes (e.g. le paclitaxel et le docétaxel (DCTX)) constituent des remèdes efficaces contre une série de tumeurs solides telles que les cancers du sein, du ...