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Coiled-coil affinity-based system for the controlled release of biofunctionalized gold nanoparticles from alginate hydrogels
(American Chemical Society, 2019-04-05)
Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled coil affinity pair to mediate the ...
Dose-dependent pharmacokinetics of ropivacaine in anesthetized rabbits : absence of changes in protein binding
(Annex Publishers, 2019-04-25)
Objective: The primary objectives of this study were to investigate the in vivo pharmacokinetics and in vitro plasma protein binding of
ropivacaine at the concentration range observed after intravenous administration of ...
Improving the use of G-CSF during chemotherapy using physiological mathematical modelling : a quantitative systems pharmacology approach
(2016-04-27)
La diminution des doses administrées ou même la cessation complète d'un traitement chimiothérapeutique est souvent la conséquence de la réduction du nombre de neutrophiles, qui sont les globules blancs les plus fréquents ...
Development of nanostructured hydrogel for spatial and temporal controlled release of active compounds
(2016-10-05)
L’utilisation de nanovecteurs pour la livraison contrôlée de principes actifs est un concept
commun de nous jours. Les systèmes de livraison actuels présentent encore cependant des
limites au niveau du taux de relargage ...
Novel surface-tethered estrogen polymeric platforms in cardiovascular regenerative medicine
(2016-04-27)
L’estradiol (E2) est une hormone femelle qui joue un rôle essentiel, à la fois dans la régulation et dans la détermination de certaines conditions physiologiques in vivo, telle que la différenciation et la prolifération ...
Pharmacokinetic/pharmacodynamic relationship of pulmonary administration methods for milrinone : a translational approach
(2018-03-23)
Suite à l'interruption de la circulation extracorporelle (CEC) chez les patients qui subissent une chirurgie cardiaque, le rétablissement de la circulation sanguine au niveau du poumon cause souvent une hypertension ...
Universal cures for idiosyncratic illnesses: a genealogy of therapeutic reasoning in the mental health field
(SAGE Publications, 2014-08)
Over the past decades, there has been a significant increase in prescriptions of psychotropic drugs for mental disorders. So far, most of the explanations of the phenomenon have focused on the process of medicalization, ...
Nonspecific interactions in biomedical applications
(Elsevier, 2019-12-20)
Nonspecific interactions play a major role in the microscale functioning of biological units. Exploiting these interactions in design and application of biomedical systems has been beneficial in different branches of ...
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)
The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic ...
Economic evaluation of benzodiazepines versus cognitive behavioural therapy among older adults with chronic insomnia
(2013-05-02)
L’insomnie, commune auprès de la population gériatrique, est typiquement traitée avec des benzodiazépines qui peuvent augmenter le risque des chutes. La thérapie cognitive-comportementale (TCC) est une intervention ...