Browsing Titles index "Frontiers in immunology"
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Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
(Frontiers Media, 2020-11-25)Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ... -
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
(Frontiers media, 2021-02-11)Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ...