Browsing Faculté de pharmacie by Author "Matyjaszewski, Krzysztof"
Now showing items 1-9 of 9
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Biomimetic bottle-brush polymer coatings for fabrication of ultra-low fouling surfaces
Xia, Yinqiang; Adibnia, Vahid; Huang, Renliang; Murschel, Frederic; Faivre, Jimmy; Xie, Guojun; Olszewski, Mateusz; De Crescenzo, Gregory; Qi, Wei; He, Zhimin; Su, Rongxin; Matyjaszewski, Krzysztof; Banquy, Xavier (Wiley, 2018-11-13)The increasing demand for long lasting antifouling surfaces has steered the development of accessible, novel, biocompatible and environmentally-friendly materials. Inspired by lubricin (LUB), a component of mammalian synovial fluid with excellent ... -
Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion
Rabanel, Jean-Michel; Mirbagheri, Marziye; Olszewski, Mateusz; Xie, Guojun; Le Goas, Marine; Latreille, Pierre-Luc; Counil, Hermine; Hervé, Vincent; Oliveira Silva, Rummenigge; Zaouter, Charlotte; Adibnia, Vahid; Acevedo, Mariana; Servant, Marc; Martinez, Vincent A.; Patten, Shunmoogum A.; Matyjaszewski, Krzysztof; Ramassamy, Charles; Banquy, Xavier (American Chemical Society, 2022-12-14)Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply penetrating into dense tissues of the CNS could potentially transform the management of neurological diseases. In the present study, we investigated the interaction of ... -
Intermolecular interactions between Bottlebrush Polymers boost the protection of surfaces against frictional wear
Faivre, Jimmy; Shrestha, Buddha R.; Xie, Guojun; Olszewski, Mateusz; Adibnia, Vahid; Moldovan, Florina; Montembault, Alexandra; Sudre, Guillaume; Delair, Thierry; David, Laurent; Matyjaszewski, Krzysztof; Banquy, Xavier (ACS Publications, 2018-05-30)Polymers exhibiting the bottlebrush (BB) architecture have excellent lubricating properties. However, to motivate their use in real life systems, they must also protect surfaces against frictional damage. In this article, we synthesized a library of ... -
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
Faivre, Jimmy; Montembault, Alexandra; Sudre, Guillaume; Shrestha, Buddha R.; Xie, Guojun; Matyjaszewski, Krzysztof; Benayoun, Stéphane; Banquy, Xavier; Delair, Thierry; David, Laurent (American Chemical Society, 2018-11-21)We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial fluid is composed of sodium hyaluronate (HA) and a bottle-brush ... -
Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis
Rahimi, Mahdi; Charmi, Gholamreza; Matyjaszewski, Krzysztof; Banquy, Xavier; Pietrasik, Joanna (Elsevier, 2021-01-12)Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in older populations and is expected to be the most dominant cause of disability in the world population by 2030. The progression of OA is controlled by a ... -
Superlubricity of zwitterionic bottlebrush polymers in the presence of multivalent ions
Adibnia, Vahid; Olszewski, Mateusz; De Crescenzo, Gregory; Matyjaszewski, Krzysztof; Banquy, Xavier (American Chemical Society, 2020-08-13)In this study, we report lubrication properties of physisorbed zwitterionic bottlebrush polymers in the presence of multivalent ions using the surface force apparatus. Unlike polyelectrolyte brushes, the lubrication properties of which diminish drastically ... -
Synergy between zwitterionic polymers and hyaluronic acid enhances antifouling performance
Xia, Yinqiang; Adibnia, Vahid; Shan, Cancan; Huang, Renliang; Qi, Wei; He, Zhimin; Xie, Guojun; Olszewski, Mateusz; De Crescenzo, Gregory; Matyjaszewski, Krzysztof; Banquy, Xavier; Su, Rongxin (American Chemical Society, 2019-09-03)Challenges associated with nonspecific adsorption of proteins on sensor surfaces have steered the development of novel antifouling materials and strategies. Inspired by human synovial fluid composition and structure, we designed synergistic antifouling ... -
Unraveling the correlations between conformation, lubrication, and chemical stability of bottlebrush polymers at interfaces
Faivre, Jimmy; Shrestha, Buddha R.; Xie, Guojun; Delair, Thierry; David, Laurent; Matyjaszewski, Krzysztof; Banquy, Xavier (American Chemical Society, 2017-09-29)In the present study, we monitored the conformation and chemical stability of a hydrophilic bottlebrush (BB) polymer in pure water and buffered saline solutions. We correlated these parameters to lubricating and wear protecting properties. Using the ... -
Wear protection without surface modification using a synergistic mixture of molecular brushes and linear polymers
Faivre, Jimmy; Shrestha, Buddha R.; Burdynska, Joanna; Xie, Guojun; Moldovan, Florina; Delair, Thierry; Benayoun, Stéphane; David, Laurent; Matyjaszewski, Krzysztof; Banquy, Xavier (American Chemical Society, 2017-01-10)We describe the design of lubricating and wear protecting fluids based on mixtures of bottlebrushes (BB) and linear polymers solutions. To illustrate this concept we used hyaluronic acid (HA) - a naturally occurring linear polyelectrolyte, and a water ...