Browsing Faculté de pharmacie by Author "Le Blanc, Jessica"

Now showing items 1-6 of 6

  • Advances in platelet function testing—light transmission aggregometry and beyond 

    Le Blanc, Jessica; Mullier, François; Vayne, Caroline; Lordkipanidzé, Marie (MDPI, 2020-08-13)
    Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light ...

  • Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment 

    Bélanger, Jean-Christophe; Bouchard, Véronique; Le Blanc, Jessica; Starnino, Louisia; Welman, Mélanie; Chabot-Blanchet, Malorie; Busseuil, David; Chertkow, Howard; D'Antono, Bianca; Lordkipanidzé, Marie (Frontiers media, 2021-09-07)
    Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), ...

  • The brain-derived neurotrophic factor prompts platelet aggregation and secretion 

    Boukhatem, Imane; Fleury, Samuel; Welman, Mélanie; Le Blanc, Jessica; Thys, Chantal; Freson, Kathleen; Best, Myron G.; Würdinger, Thomas; Allen, Bruce G.; Lordkipanidzé, Marie (American Society of Hematology, 2021-09-21)
    Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in neurons, and its release and signaling mechanisms have been extensively studied in the central nervous system. Large quantities of BDNF have been reported in ...

  • Platelet function in aging 

    Le Blanc, Jessica; Lordkipanidzé, Marie (Frontiers Media, 2019-08-07)
    Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that ...

  • Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF 

    Le Blanc, Jessica; Fleury, Samuel; Boukhatem, Imane; Bélanger, Jean‐Christophe; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers Media, 2020-11-25)
    Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ...

  • Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases 

    Fleury, Samuel; Boukhatem, Imane; Le Blanc, Jessica; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers media, 2021-02-11)
    Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ...