Now showing items 1-20 of 31

  • 2D, 3D and 4D active compound delivery in tissue engineering and regenerative medicine 

    Hanauer, Nicolas; Latreille, Pierre-Luc; Alsharif, Shaker; Banquy, Xavier (2015-07-01)
    Recent advances in tissue engineering and regenerative medicine have shown that controlling cells microenvironment during growth is a key element to the development of successful therapeutic system. To achieve such control, researchers have first ...
  • Assessment of PEG on Polymeric Particles Surface, a Key Step in Drug Carrier Translation 

    Rabanel, Jean-Michel; Hildgen, Patrice; Banquy, Xavier (2014-07)
    Injectable drug nanocarriers have greatly benefited in their clinical development from the addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The most studied and used polymer for this purpose is poly(ethylene glycol), ...
  • Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release 

    Cunningham, Alexander J.; Robinson, Mattieu; Banquy, Xavier; Leblond-Chain, Jeanne; Zhu, X. X. (American Chemical Society, 2018-01-29)
    Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block copolymers present certain advantages ...
  • Bioinspired microstructures of chitosan hydrogel provide enhanced wear protection 

    Faivre, Jimmy; Sudre, Guillaume; Montembault, Alexandra; Benayoun, Stéphane; Banquy, Xavier; Delair, Thierry; David, Laurent (Royal Society of Chemistry, 2018-02-16)
    We describe the fabrication of physical chitosan hydrogels exhibiting a layered structure. This bilayered structure, as shown by SEM and confocal microscopy, is composed of a thin dense superficial zone (SZ), covering a deeper zone (DZ) containing ...
  • Biomimetic bottle-brush polymer coatings for fabrication of ultra-low fouling surfaces 

    Xia, Yinqiang; Adibnia, Vahid; Huang, Renliang; Murschel, Frederic; Faivre, Jimmy; Xie, Guojun; Olszewski, Mateusz; De Crescenzo, Gregory; Qi, Wei; He, Zhimin; Su, Rongxin; Matyjaszewski, Krzysztof; Banquy, Xavier (Wiley, 2018-11-13)
    The increasing demand for long lasting antifouling surfaces has steered the development of accessible, novel, biocompatible and environmentally-friendly materials. Inspired by lubricin (LUB), a component of mammalian synovial fluid with excellent ...
  • Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis 

    Thrombocytopenia in acute coronary syndromes
    Discepola, Vanessa; Schnitzer, Mireille; Jolicoeur, Marc; Rousseau, Guy; Lordkipanidzé, Marie (Taylor & Francis, 2018-10-22)
    Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence on the clinical importance of ...
  • Drug-loaded nanocarriers : passive targeting and crossing of biological barriers 

    Rabanel, Jean-Michel; Aoun, Valery; Elkin, Igor; Mokhtar, Mohamed; Hildgen, Patrice (2012-12)
    Poor bioavailability and poor pharmacokinetic characteristics are some of the leading causes of drug development failure. Therefore, poorly-soluble drugs, fragile proteins or nucleic acid products may benefit from their encapsulation in nanosized ...
  • Effect of polymer architecture on Curcumin 1 encapsulation and release from PEGylated polymer nanoparticles: toward a drug delivery nano-platform to the CNS 

    Rabanel, Jean-Michel; Faivre, Jimmy; Djiokeng Paka, Ghislain; Ramassamy, Charles; Hildgen, Patrice; Banquy, Xavier (2015-10-01)
    We developed a nanoparticles (NPs) library from poly(ethylene glycol)–poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative ...
  • Effect of Polymer Architecture on the Structural and Biophysical Properties of PEG-PLA Nanoparticles 

    Rabanel, Jean-Michel; Faivre, Jimmy; Tehrani, Soudeh F.; Lalloz, Augustine; Hildgen, Patrice; Banquy, Xavier (2015-05-01)
    Polymers made of poly(ethylene glycol) chains grafted to poly(lactic acid) chains (PEG-g-PLA) were used to produce stealth drug nanocarriers. A library of comb-like PEG-g-PLA polymers with different PEG grafting densities was prepared in order to obtain ...
  • Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol 

    Lalloz, Augustine; Bolzinger, Marie-Alexandrine; Faivre, Jimmy; Latreille, Pierre-Luc; García Ac, Araceli; Rakotovao, Cyrielle; Rabanel, Jean-Michel; Hildgen, Patrice; Banquy, Xavier; Briançon, Stéphanie (Elsevier, 2018-10-11)
    We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ...
  • Factors associated with psychotropic drug use among community-dwelling older persons: A review of empirical studies 

    Voyer, Philippe; Cohen, David; Lauzon, Sylvie; Collin, Johanne (2004)
    BACKGROUND:In the many descriptive studies on prescribed psychotropic drug use by community-dwelling older persons, several sociodemographic and other factors associated with drug use receive inconsistent support.METHOD:Empirical reports with data on ...
  • Hydration forces at solid and fluid biointerfaces 

    Shrestha, Buddha R.; Banquy, Xavier (American Vacuum Society, 2016-01)
    We review the different molecular mechanisms giving rise to the repulsive hydration force between biologically relevant surfaces such as lipid bilayers and bio-ceramics. As we will show, the hydration force manifests itself in very different and ...
  • Insiders, smart drugs et pharmaceuticalisation : éléments pour une typologie de la nouvelle déviance conformiste 

    Otero, Marcelo; Collin, Johanne (Département de sociologie de l’Université du Québec à Montréal & Athéna éditions, 2016)
    La multiplication des usagers et usagères des smart drugs sur les campus universitaires, des go-pills dans l’armée ou encore des coast-to-coast chez les camionneurs de longue distance invite à revisiter la légitimité croissante des « usages adaptatifs ...
  • Interaction forces between pegylated star-shaped polymers at mica surfaces 

    Banquy, Xavier; Le Dévédec, Frantz; Cheng, Hsiu-Wei; Faivre, Jimmy; Zhu, Julian X.X.; Valtiner, Markus (American Chemical Society, 2017-08-03)
    We present a study focused on characterizing the interaction forces between mica surfaces across solutions containing star-shaped polymers with cationic ends. Using the Surface Forces Apparatus, we show that the interaction forces in pure water between ...
  • Intermolecular interactions between Bottlebrush Polymers boost the protection of surfaces against frictional wear 

    Faivre, Jimmy; Shrestha, Buddha R.; Xie, Guojun; Olszewski, Mateusz; Adibnia, Vahid; Moldovan, Florina; Montembault, Alexandra; Sudre, Guillaume; Delair, Thierry; David, Laurent; Matyjaszewski, Krzysztof; Banquy, Xavier (ACS Publications, 2018-05-30)
    Polymers exhibiting the bottlebrush (BB) architecture have excellent lubricating properties. However, to motivate their use in real life systems, they must also protect surfaces against frictional damage. In this article, we synthesized a library of ...
  • Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids 

    Faivre, Jimmy; Montembault, Alexandra; Sudre, Guillaume; Shrestha, Buddha R.; Xie, Guojun; Matyjaszewski, Krzysztof; Benayoun, Stéphane; Banquy, Xavier; Delair, Thierry; David, Laurent (American Chemical Society, 2018-11-21)
    We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial fluid is composed of sodium hyaluronate (HA) and a bottle-brush ...
  • Mechanistic insights into the directed assembly of hydrogel blocks mediated by polyelectrolytes or microgels 

    Hanauer, Nicolas; Latreille, Pierre-Luc; Banquy, Xavier (2017-04-18)
    In this study, we report the directed assembly of hydrogel blocks mediated by electrostatic interactions. We compared two different assembly mechanisms, one mediated by microgel particles and another mediated by direct interaction between ...
  • Nanonization of megestrol acetate by laser fragmentation in aqueous milieu 

    Sylvestre, Jean-Philippe; Tang, Marie-Christine; Furtos, Alexandra; Leclair, Grégoire; Meunier, Michel; Leroux, Jean-Christophe (2011-02-10)
    Nanonization is a simple and effective method to improve dissolution rate and oral bioavailability of drugs with poor water solubility. There is growing interest to downscale the nanocrystal production to enable early preclinical evaluation of new ...
  • Non-covalent formulation of active principles with dendrimers: current state-of-the-art and prospects for further development 

    Elkin, Igor; Banquy, Xavier; Barrett, Christopher J.; Hildgen, Patrice (Elsevier, 2017-09-06)
    During the last three decades, dendrimers, nano-sized highly-branched fractal-like symmetrical macromolecules, have been intensively studied as promising candidates for application as drug-delivery carriers. Among other important characteristics arising ...
  • Platelet function in aging 

    Le Blanc, Jessica; Lordkipanidzé, Marie (Frontiers Media, 2019-08-07)
    Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that ...