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TGF-beta superfamily and limb regeneration : TGF-beta to start and BMP to end
(Wiley, 2021-06-07)
Axolotls represent a popular model to study how nature solved the problem of regenerating lost appendages in tetrapods. Our work over many years focused on trying to understand how these animals can achieve such a feat and ...
Tissue regeneration in dentistry: can salamanders provide insight?
(2017-04-29)
The ability to regenerate damaged tissues would be of tremendous benefit for medicine
and dentistry. Unfortunately, humans are unable to regenerate tissues such teeth, fingers or to
repair injured spinal cord. With an ...
Senescence gives insights into the morphogenetic evolution of anamniotes
(2017)
Senescence represents a mechanism to avoid undesired cell
proliferation that plays a role in tumor suppression, wound healing
and embryonic development. In order to gain insight on the evolution
of senescence, we looked ...
Activation of Smad2 but not Smad3 is required to mediate TGF-β signaling during axolotl limb regeneration
(2016-10-01)
Axolotls are unique among vertebrates in their ability to regenerate
tissues, such as limbs, tail and skin. The axolotl limb is the most
studied regenerating structure. The process is well characterized
morphologically; ...
Oral-facial tissue reconstruction in the regenerative axolotl
(2016-12)
Absence of large amounts of orofacial tissues caused by cancerous resections, congenital
defects or trauma result in sequelae such as dysphagia and noticeable scars. Oral-neck tissue
regeneration was studied in the axolotl ...