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Characterization of Endoproteolytic Processing of Dynorphins by Proprotein Convertases using Mouse Spinal Cord S9 Fractions and Mass Spectrometry
(2016-06-01)
Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely ...
Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions
(2015-11-01)
Substance P (SP) play a central role in nociceptive transmission and it is an agonist of the
Neurokinin-1 receptor located in the lamina I of the spinal cord. SP is a major proteolytic product
of the protachykinin-1 ...