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Resiniferatoxin hampers the nocifensive response of Caenorhabditis elegans to noxious heat, and pathway analysis revealed that the Wnt signaling pathway is involved
(Springer, 2021-10-25)
Resiniferatoxin (RTX) is a metabolite extracted from Euphorbia resinifera. RTX is a potent capsaicin analog with specific biological activities resulting from its agonist activity with the transient receptor potential ...
Is nontargeted data acquisition for target analysis (nDATA) in mass spectrometry a forward-thinking analytical approach?
(Wiley, 2022-10-21)
Targeted mass spectrometry is extensively used for the quantitative measurement of various molecules present in complex matrices. It is certainly one of the most important analytical duties in a mass spectrometry laboratory. ...
Proteomics reveals long-term alterations in signaling and metabolic pathways following both myocardial infarction and chemically induced denervation
(Elsevier, 2022-06-18)
Myocardial infraction (MI) is the principal risk factor for the onset of heart failure (HF). Investigations regarding the physiopathology of MI progression to HF have revealed the concerted engagement of other tissues, ...
Antinociceptive activity of vanilloids in caenorhabditis elegans is mediated by the desensitization of the TRPV channel OCR-2 and specific signal transduction pathways
(Springer, 2023-02-03)
Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged treatment with vanilloids triggered the desensitization of TRPV1, leading to ...