Browsing Faculté de médecine vétérinaire by Author "Saidi, Mouna"
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Étude de la régulation des tachykinines et son impact sur l’expression des peptides opioïdes à l'aide de la chromatographie liquide à haute performance et de la spectrométrie de masse
Saidi, Mouna (2017-10-04)Les peptides appartenant à la famille des tachykinines telle que la substance P (SP) sont des acteurs essentiels contribuant à l’hyperalgésie primaire et secondaire. La SP libérée par les neurones afférents primaires, ne provoque pas à elle seule des ... -
Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides
Saidi, Mouna; Beaudry, Francis (2015-08)Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ... -
Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions
Saidi, Mouna; Kamali, Soufiane; Ruiz Orduna, Alberto; Beaudry, Francis (2015-11-01)Substance P (SP) play a central role in nociceptive transmission and it is an agonist of the Neurokinin-1 receptor located in the lamina I of the spinal cord. SP is a major proteolytic product of the protachykinin-1 primarily synthesized in neurons. ...