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dc.contributor.authorBen Salem, Jennifer
dc.contributor.authorIacovoni, Jason S.
dc.contributor.authorCalise, Denis
dc.contributor.authorArvanitis, Dina N.
dc.contributor.authorBeaudry, Francis
dc.date.accessioned2022-06-21T12:58:13Z
dc.date.availableMONTHS_WITHHELD:12fr
dc.date.available2022-06-21T12:58:13Z
dc.date.issued2022-06-18
dc.identifier.urihttp://hdl.handle.net/1866/26700
dc.publisherElsevierfr
dc.subjectMyocardial infarctionfr
dc.subjectHeart failurefr
dc.subjectResiniferatoxin (RTX)fr
dc.subjectTransient receptor potential vanillId subtype 1 (TRPV1) (TRPV1)fr
dc.subjectProteomicsfr
dc.subjectMass spectrometryfr
dc.subjectBioinformaticsfr
dc.subjectIntegrative biologyfr
dc.subjectAutonomic nervous systemfr
dc.titleProteomics reveals long-term alterations in signaling and metabolic pathways following both myocardial infarction and chemically induced denervationfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine vétérinairefr
dc.identifier.doi10.1007/s11064-022-03636-7
dcterms.abstractMyocardial infraction (MI) is the principal risk factor for the onset of heart failure (HF). Investigations regarding the physiopathology of MI progression to HF have revealed the concerted engagement of other tissues, such as the autonomic nervous system and the medulla oblongata (MO), giving rise to systemic effects, important in the regulation of heart function. Cardiac sympathetic afferent denervation following application of resiniferatoxin (RTX) attenuates cardiac remodelling and restores cardiac function following MI. While the physiological responses are well documented in numerous species, the underlying molecular responses during the initiation and progression from MI to HF remains unclear. We obtained multi-tissue time course proteomics with a murine model of HF induced by MI in conjunction with RTX application. We isolated tissue sections from the left ventricle (LV), MO, cervical spinal cord and cervical vagal nerves at four time points over a 12-week study. Bioinformatic analyses consistently revealed a high statistical enrichment for metabolic pathways in all tissues and treatments, implicating a central role of mitochondria in the tissue-cellular response to both MI and RTX. In fact, the additional functional pathways found to be enriched in these tissues, involving the cytoskeleton, vesicles and signal transduction, could be downstream of responses initiated by mitochondria due to changes in neuronal pulse frequency after a shock such as MI or the modification of such frequency communication from the heart to the brain after RTX application. Development of future experiments, based on our proteomic results, should enable the dissection of more precise mechanisms whereby metabolic changes in neuronal and cardiac tissues can effectively ameliorate the negative physiological effects of MI via RTX application.fr
dcterms.isPartOfurn:ISSN:0364-3190fr
dcterms.isPartOfurn:ISSN:1573-6903fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantJ. Ben Salem, J. S. Iacovoni, D. Calise, D. N. Arvanitis, F. Beaudry (2022). Proteomics reveals long-term alterations in signaling and metabolic pathways following both myocardial infarction and chemically induced denervation. Neurochemical Research. In press https://doi.org/10.1007/s11064-022-03636-7fr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitleNeurochemical researchfr


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