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dc.contributor.authorBarboza-Solis, Catalina
dc.contributor.authorNajimudeen, Shahnas M.
dc.contributor.authorPerez-Contreras, Ana
dc.contributor.authorJoseph, Tomy
dc.contributor.authorKing, Robin
dc.contributor.authorRavi, Madhu
dc.contributor.authorPeters, Delores
dc.contributor.authorFonseca, Kevin
dc.contributor.authorGagnon, Carl A.
dc.contributor.authorVan der Meer, Frank
dc.contributor.authorAbdul-Careem, Mohamed Faizal
dc.date.accessioned2022-03-01T15:44:39Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2022-03-01T15:44:39Z
dc.date.issued2021-12-03
dc.identifier.urihttp://hdl.handle.net/1866/26350
dc.publisherMDPIfr
dc.rightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectInfectious laryngotracheitis virusfr
dc.subjectrHVT-LT recombinant vaccinefr
dc.subjectChickenfr
dc.subjectImmune responsefr
dc.titleEvaluation of recombinant Herpesvirus of Turkey Laryngotracheitis (rHVT-LT) Vaccine against Genotype VI Canadian Wild-Type Infectious Laryngotracheitis Virus (ILTV) Infectionfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine vétérinairefr
dc.identifier.doi10.3390/vaccines9121425
dcterms.abstractIn Alberta, infectious laryngotracheitis virus (ILTV) infection is endemic in backyard poultry flocks; however, outbreaks are only sporadically observed in commercial flocks. In addition to ILTV vaccine revertant strains, wild-type strains are among the most common causes of infectious laryngotracheitis (ILT). Given the surge in live attenuated vaccine-related outbreaks, the goal of this study was to assess the efficacy of a recombinant herpesvirus of turkey (rHVT-LT) vaccine against a genotype VI Canadian wild-type ILTV infection. One-day-old specific pathogen-free (SPF) White Leghorn chickens were vaccinated with the rHVT-LT vaccine or mock vaccinated. At three weeks of age, half of the vaccinated and the mock-vaccinated animals were challenged. Throughout the experiment, weights were recorded, and feather tips, cloacal and oropharyngeal swabs were collected for ILTV genome quantification. Blood was collected to isolate peripheral blood mononuclear cells (PBMC) and quantify CD4+ and CD8+ T cells. At 14 dpi, the chickens were euthanized, and respiratory tissues were collected to quantify genome loads and histological examination. Results showed that the vaccine failed to decrease the clinical signs at 6 days post-infection. However, it was able to significantly reduce ILTV shedding through the oropharyngeal route. Overall, rHVT-LT produced a partial protection against genotype VI ILTV infection.fr
dcterms.isPartOfurn:ISSN:2076-393Xfr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantBarboza-Solis C, Najimudeen SM, Perez-Contreras A, Ali A, Joseph T, King R, Ravi M, Peters D, Fonseca K, Gagnon CA, van der Meer F, Abdul-Careem MF. Evaluation of Recombinant Herpesvirus of Turkey Laryngotracheitis (rHVT-LT) Vaccine against Genotype VI Canadian Wild-Type Infectious Laryngotracheitis Virus (ILTV) Infection. Vaccines (Basel). 2021 Dec 3;9(12):1425. doi: 10.3390/vaccines9121425. PMID: 34960175; PMCID: PMC8707389.fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleVaccinesfr
oaire.citationVolume9fr


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Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
RightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.

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