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H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations
(2018-03-12)Neomorphic missense mutations affecting crucial lysine residues in histone H3 genes have been shown to be initiating mutation in a variety of solid tumors. Despite the high prevalence of H3K27M mutations in pediatric glioblastoma proceeded by the loss ...