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dc.contributor.authorIdrissi Janati, Amal
dc.contributor.authorKarp, Igor
dc.contributor.authorLaprise, Claudie
dc.contributor.authorSabri, Hisham
dc.contributor.authorEmami, Elham
dc.date.accessioned2020-12-15T13:15:08Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2020-12-15T13:15:08Z
dc.date.issued2020-12-03
dc.identifier.urihttp://hdl.handle.net/1866/24088
dc.publisherBMCfr
dc.rightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectColorectal cancerfr
dc.subjectFusobacterium nucleatumfr
dc.subjectSystematic reviewfr
dc.subjectMeta-analysisfr
dc.titleDetection of Fusobacterium nucleatum in feces and colorectal mucosa as a risk factor for colorectal cancer : a systematic review and meta-analysisfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine dentairefr
dc.identifier.doi10.1186/s13643-020-01526-z
dcterms.abstractBackground: Colorectal cancer (CRC) is a major cause of cancer deaths worldwide. Accumulating evidence suggests a potentially important role of colorectal infection with Fusobacterium nucleatum (F. nucleatum) in colorectal carcinogenesis. We conducted a systematic review, including both a qualitative synthesis and a metaanalysis, to synthesize the evidence from the epidemiological literature on the association between F. nucleatum detection in the colon/rectum and CRC. Methods: A systematic literature search of Ovid MEDLINE(R), Embase, Web of Science Core Collection, EBM Reviews—Cochrane Database of Systematic Reviews, and CINAHL Plus with Full Text was conducted using earliest inclusive dates up to 4 October 2020. Eligible studies were original, comparative observational studies that reported results on colorectal F. nucleatum detection and CRC. Two independent reviewers extracted the relevant information. Odds ratio (OR) estimates were pooled across studies using the random effects model. NewcastleOttawa scale was used to critically appraise study quality. Results: Twenty-four studies were included in the systematic review, of which 12 were included in the metaanalysis. Studies investigated F. nucleatum in feces, colorectal tissue samples, or both. In most studies included in the systematic review, the load of F. nucleatum was higher, on average, in specimens from CRC patients than in those from CRC-free controls. Meta-analysis showed a positive association between F. nucleatum detection in colorectal specimens and CRC (OR = 8.3; 95% confidence interval (95% CI) 5.2 to 13.0). Conclusions: The results of this systematic review suggest that F. nucleatum in the colon/rectum is associated with CRC.fr
dcterms.isPartOfurn:ISSN:2046-4053fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantDOI: 10.1186/s13643-020-01526-zfr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleSystematic reviewsfr
oaire.citationVolume9fr


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Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
RightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.

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