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dc.contributor.authorVilliard, Éric
dc.contributor.authorDenis, Jean-François
dc.contributor.authorHashemi, Faranak Sadat
dc.contributor.authorIgelmann, Sebastian
dc.contributor.authorFerbeyre, Gerardo
dc.contributor.authorRoy, Stéphane
dc.date.accessioned2017-11-02T19:35:06Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2017-11-02T19:35:06Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/1866/19572
dc.subjectAxolotlfr
dc.subjectEvolutionfr
dc.subjectMorphogenesisfr
dc.subjectPronephrosfr
dc.subjectSenescencefr
dc.subjectZebrafishfr
dc.titleSenescence gives insights into the morphogenetic evolution of anamniotesfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine dentairefr
UdeM.statutProfesseur(e) / Professorfr
dc.identifier.doi10.1242/bio.025809
dcterms.abstractSenescence represents a mechanism to avoid undesired cell proliferation that plays a role in tumor suppression, wound healing and embryonic development. In order to gain insight on the evolution of senescence, we looked at its presence in developing axolotls (urodele amphibians) and in zebrafish (teleost fish), which are both anamniotes. Our data indicate that cellular senescence is present in various developing structures in axolotls (pronephros, olfactory epithelium of nerve fascicles, lateral organs, gums) and in zebrafish (epithelium of the yolk sac and in the lower part of the gut). Senescence was particularly associated with transient structures (pronephros in axolotls and yolk sac in zebrafish) suggesting that it may play a role in the elimination of these tissues. Our data supports the notion that cellular senescence evolved early in vertebrate evolution to influence embryonic development.fr
dcterms.isPartOfurn:ISSN:2046-6390
dcterms.languageengfr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscript
oaire.citationTitleBiology open
oaire.citationVolume6
oaire.citationStartPage891
oaire.citationEndPage896


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