Senescence gives insights into the morphogenetic evolution of anamniotes
dc.contributor.author | Villiard, Éric | |
dc.contributor.author | Denis, Jean-François | |
dc.contributor.author | Hashemi, Faranak Sadat | |
dc.contributor.author | Igelmann, Sebastian | |
dc.contributor.author | Ferbeyre, Gerardo | |
dc.contributor.author | Roy, Stéphane | |
dc.date.accessioned | 2017-11-02T19:35:06Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2017-11-02T19:35:06Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/1866/19572 | |
dc.subject | Axolotl | fr |
dc.subject | Evolution | fr |
dc.subject | Morphogenesis | fr |
dc.subject | Pronephros | fr |
dc.subject | Senescence | fr |
dc.subject | Zebrafish | fr |
dc.title | Senescence gives insights into the morphogenetic evolution of anamniotes | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine dentaire | fr |
UdeM.statut | Professeur(e) / Professor | fr |
dc.identifier.doi | 10.1242/bio.025809 | |
dcterms.abstract | Senescence represents a mechanism to avoid undesired cell proliferation that plays a role in tumor suppression, wound healing and embryonic development. In order to gain insight on the evolution of senescence, we looked at its presence in developing axolotls (urodele amphibians) and in zebrafish (teleost fish), which are both anamniotes. Our data indicate that cellular senescence is present in various developing structures in axolotls (pronephros, olfactory epithelium of nerve fascicles, lateral organs, gums) and in zebrafish (epithelium of the yolk sac and in the lower part of the gut). Senescence was particularly associated with transient structures (pronephros in axolotls and yolk sac in zebrafish) suggesting that it may play a role in the elimination of these tissues. Our data supports the notion that cellular senescence evolved early in vertebrate evolution to influence embryonic development. | fr |
dcterms.isPartOf | urn:ISSN:2046-6390 | |
dcterms.language | eng | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Biology open | |
oaire.citationVolume | 6 | |
oaire.citationStartPage | 891 | |
oaire.citationEndPage | 896 |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.