Browsing Faculté de médecine vétérinaire – Travaux et publications by Author "Côté, Marie-France"

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Microtubule disrupting N-phenyl-N’-(2-chloroethyl) ureas display anticancer activity on cell adhesion, P-glycoprotein and BCL-2-mediated drug resistance

Fortin, Jessica; Côté, Marie-France; Deschesnes, Réna G.; Patenaude, Alexandre; Lacroix, Jacques; Benoit-Biancamano, Marie-Odile; C.-Gaudreault, René (2014-04)

Objective: Our research program has focused on the development of promising, soft alkylating N-phenyl-N’-(2-chloroethyl)urea (CEU) compounds which acylate the glutamic acid-198 of β-tubulin, near the binding site of colchicum alkaloids. CEUs inhibit ...