Browsing Faculté de médecine vétérinaire – Travaux et publications by Author "Savard, Christian"
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Capsular sialic acid of Streptococcus suis serotype 2 binds to swine influenza virus and enhances bacterial interactions with virus-infected tracheal epithelial cells
Wang, Yingchao; Gagnon, Carl A.; Savard, Christian; Music, Nedzad; Srednik, Mariela; Segura, Mariela; Lachance, Claude; Bellehumeur, Christian; Gottschalk, Marcelo (2013-12)Streptococcus suis serotype 2 is an important swine bacterial pathogen, and it is also an emerging zoonotic agent. It is unknown how S. suis virulent strains, which are usually found in low quantities in pig tonsils, manage to cross the first host ... -
Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine
Savard, Christian; Gagnon, Carl A.; Chorfi, Younès (2015-07-31)Cereal commodities are frequently contaminated with mycotoxins produced by the secondary metabolism of fungal infection. Among these contaminants, deoxynivalenol (DON), also known as vomitoxin, is the most prevalent type B trichothecene mycotoxin ... -
Effect of deoxynivalenol (DON) mycotoxin on in vivo and in vitro porcine circovirus type 2 infections
Savard, Christian; Provost, Chantale; Alvarez, Fernando; Pinilla, Vicente; Music, Nedzad; Jacques, Mario; Gagnon, Carl A.; Chorfi, Younès (2015-04)Deoxynivalenol (DON) is a mycotoxin produced by Fusarium spp and is a common contaminant of grains in North America. Among farm animals, swine are the most susceptible to DON because it markedly reduces feed intake and decreases weight gain. Porcine ... -
First report and genomic characterization of a bovine-like coronavirus causing enteric infection in an odd-toed non ruminant species (Indonesian tapir, Acrocodia indica) during an outbreak of winter dysentery in a zoo
Savard, Christian; Provost, Chantale; Ariel, Olivier; Morin, Samuel; Fredrickson, Richard; Gagnon, Carl A.; Broes, André; Wang, Leyi (Wiley, 2021-08-24)Bovine Coronavirus (BCoV) is associated with three distinct clinical syndromes in cattle i.e. neonatal diarrhea, hemorrhagic diarrhea in adults (the so-called winter dysentery syndrome, WD) and respiratory infections in cattle of different ages. In ... -
FosteraTM PRRS modified live vaccine efficacy against a Canadian heterologous virulent field strain of porcine reproductive and respiratory syndrome virus (PRRSV)
Savard, Christian; Alvarez, Fernando; Provost, Chantale; Chorfi, Younès; D'Allaire, Sylvie; Benoit-Biancamano, Marie-Odile; Gagnon, Carl A. (2016-01-01)Vaccination is a useful option to control infection with porcine reproductive and respiratory syndrome virus (PRRSV), and several modified live-PRRSV vaccines have been developed. These vaccines have shown some efficacy in reducing the incidence and ... -
Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine
Lessard, Martin; Savard, Christian; Deschene, Karine; Lauzon, Karoline; Pinilla, Vicente; Gagnon, Carl A.; Lapointe, Jérôme; Guay, Frédéric; Chorfi, Younès (Elsevier, 2015-02-17)This study was performed to characterize the influence of consuming DON naturally contaminated feeds on pig's intestinal immune defenses, antibody response and cellular immunity. Sixteen 4-week-old piglets were randomly allocated to two dietary treatments: ... -
In vitro effect of deoxynivalenol (DON) mycotoxin on porcine reproductive and respiratory syndrome virus replication
Savard, Christian; Pinilla, Vicente; Provost, Chantale; Segura, Mariela; Gagnon, Carl A.; Chorfi, Younès (2014-03)Deoxynivalenol (DON) is a mycotoxin produced by Fusarium spp. Among monogastric farm animals, swine are the most susceptible to DON as it markedly reduces feed intake and decreases weight gain. DON has also been shown to increase susceptibility to ... -
In vivo effect of deoxynivalenol (DON) naturally contaminated feed on porcine reproductive and respiratory syndrome virus (PRRSV) infection
Savard, Christian; Pinilla, Vicente; Provost, Chantale; Gagnon, Carl A.; Chorfi, Younès (2014-12-05)Deoxynivalenol (DON), also known as vomitoxin, is the most prevalent type B trichothecene mycotoxin worldwide. Pigs show a great sensitivity to DON, and because of the high proportion of grains in their diets, they are frequently exposed to this ... -
Transcriptional approach to study porcine tracheal epithelial cells individually or dually infected with swine influenza virus and Streptococcus suis
Dang, Yuan; Lachance, Claude; Wang, Yingchao; Gagnon, Carl A.; Savard, Christian; Segura, Mariela; Grenier, Daniel; Gottschalk, Marcelo (2014-04)Background: Swine influenza is a highly contagious viral infection in pigs affecting the respiratory tract that can have significant economic impacts. Streptococcus suis serotype 2 is one of the most important post-weaning bacterial pathogens in swine ...