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Hepatic encephalopathy : from metabolic to neurodegenerative
(Elsevier, 2021-06-15)
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome of both acute and chronic liver disease. As a metabolic disorder, HE is considered to be reversible and therefore is expected to resolve following the replacement ...
Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile‐duct ligated rats
(Wiley, 2021-02-06)
Hyperammonemia associated with chronic liver disease (CLD) is implicated in the pathogenesis of hepatic encephalopathy (HE). The gut is a major source of ammonia production that contributes to hyperammonemia in CLD and HE ...
The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis
(Elsevier, 2019-10-04)
Objectives
Hepatokines are proteins secreted by the liver that impact the functions of the liver and various tissues through autocrine, paracrine, and endocrine signaling. Recently, Tsukushi (TSK) was identified as a new ...
Glycine and hyperammonemia : potential target for the treatment of hepatic encephalopathy
(Springer, 2016-06-23)
Hepatic encephalopathy (HE) is a neuropsychiatric
disorder caused by hepatic dysfunction. Numerous studies
dictate that ammonia plays an important role in the pathogenesis of HE, and hyperammonemia can lead to alterations ...
Ammonia‐lowering strategies for the treatment of hepatic encephalopathy
(Wiley, 2012-08-08)
Hyperammonemia leads to neurotoxic levels of brain ammonia and is a major factor involved in the pathogenesis of hepatic encephalopathy (HE). Ammonia‐lowering treatments primarily involve two strategies: inhibiting ammonia ...
Proceedings from the 2018 Canadian Association for the Study of the Liver Single Topic Conference—Decompensated Cirrhosis : from clinic to transplant
(Canadian Association for the Study of the Liver, 2019)
Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs
(Springer, 2004-01-21)
Abstract Objective: Although water-soluble drugs can be removed by
haemofiltration/haemodialysis, morbidity and mortality from intoxication
with protein-bound drugs remains
high. The present study investigates
whether ...
The Portacaval‐shunted rat : a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?
(Wiley, 1997-04)
Portacaval anastomosis (PCA) is a surgical procedure whereby blood from the portal vein is shunted into the inferior vena cava. PCA in the rat results in a significant increase (from 0.77 ± 0.26 to 3.51 ± 0.37 g of ...
Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis
(Wiley, 2017-06-30)
Background & Aims
Recent studies suggest that heparins reduce liver fibrosis and the risk of decompensation of liver disease. Here, we evaluated the effects of enoxaparin in several experimental models of advanced ...
2021 ISHEN guidelines on animal models of hepatic encephalopathy
(Wiley, 2021-04-01)
This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models ...