Search
Now showing items 1-10 of 64
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: In vivo mouse model
(2009)
The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of cancer-associated proteins, PCs play key roles in multiple steps of ...
2021 ISHEN guidelines on animal models of hepatic encephalopathy
(Wiley, 2021-04-01)
This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models ...
Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats
(Wiley, 2013-11-25)
Background & Aims The pathogenesis of hepatic encephalopathy (HE) is multifactorial and often associated with the
development of brain oedema. In addition to ammonia playing a central role, systemic oxidative stress is ...
Bile‐duct ligation renders the brain susceptible to hypotension induced neuronal degeneration : implications of ammonia
Hypotension in hepatic encephalopathy
(Wiley, 2020-12-31)
Hepatic encephalopathy (HE) is a debilitating neurological complication of cirrhosis. By definition, HE is considered a reversible disorder, and therefore HE should resolve following liver transplantation (LT). However, ...
Ten simple rules for conducting a mendelian randomization study
(Public Library of Science, 2021)
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver
failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation,
but ...
Astrocyte glutamine synthetase : pivotal in health and disease
(Portland Press, 2013)
The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and ...
Nutritional strategies to manage malnutrition and sarcopenia following liver transplantation : a narrative review
(MDPI, 2023-02-10)
Persisting or newly developed malnutrition and sarcopenia after liver transplant (LT) are correlated with adverse health outcomes. This narrative review aims to examine the literature regarding nutrition strategies to ...
Development and disease of the photoreceptor cilium
(2009)
Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding ...
Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats
(Wiley, 2022-06-30)
Hepatic encephalopathy (HE) is a debilitating neurological complication of chronic liver disease (CLD). Hyperammonemia plays an important role in HE’s pathogenesis, acting synergistically with systemic oxidative stress. ...