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Hepatic encephalopathy : from metabolic to neurodegenerative
(Elsevier, 2021-06-15)
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome of both acute and chronic liver disease. As a metabolic disorder, HE is considered to be reversible and therefore is expected to resolve following the replacement ...
Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile‐duct ligated rats
(Wiley, 2021-02-06)
Hyperammonemia associated with chronic liver disease (CLD) is implicated in the pathogenesis of hepatic encephalopathy (HE). The gut is a major source of ammonia production that contributes to hyperammonemia in CLD and HE ...
2021 ISHEN guidelines on animal models of hepatic encephalopathy
(Wiley, 2021-04-01)
This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models ...
Hepatic encephalopathy : novel insights into classification, pathophysiology and therapy
(Elsevier, 2020-10-21)
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild ...
Progressive resistance training prevents loss of muscle mass and strength in bile duct‐ligated rats
(Wiley, 2018-11-05)
BACKGROUND: Loss of muscle mass and strength is common in cirrhosis and increases
the risk of hyperammonaemia and hepatic encephalopathy. Resistance training
optimizes muscle mass and strength in several ...
Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats
(Wiley, 2013-11-25)
Background & Aims The pathogenesis of hepatic encephalopathy (HE) is multifactorial and often associated with the
development of brain oedema. In addition to ammonia playing a central role, systemic oxidative stress is ...
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver
failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation,
but ...
Judging the value of ammonia measurement on lactulose dosing : apples and oranges?
(University of Toronto Press, 2021-02-24)
Heretical thoughts into hepatic encephalopathy
(Elsevier & European Association for the Study of the Liver, 2022-03-27)
Clinical progress in the development of new diagnostic modalities and therapeutic strategies for the management of patients with hepatic encephalopathy has lagged behind the vast knowledge that has been generated from basic ...
Amino acids, ammonia, and hepatic encephalopathy
(Elsevier, 2022-04-30)
Hepatic encephalopathy (HE) is a decline in brain function arising due to liver insufficiency. The liver's diminished capacity to clear ammonia, and the subsequent accumulation of it, is highly implicated in pathogenesis ...