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2021 ISHEN guidelines on animal models of hepatic encephalopathy
(Wiley, 2021-04-01)
This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models ...
Elevated serum liver-type fatty acid binding protein levels in non-acetaminophen acute liver failure patients with organ dysfunction.
(Springer, 2020-03-03)
Liver-type fatty acid binding protein (FABP1) has previously been
demonstrated to improve prognostic discrimination in acetaminophen (APAP)-induced
ALF but has not been investigated in other etiologies of ...
Keeping cool in acute liver failure: rationale for the use of mild hypothermia
(2005)
Encephalopathy, brain edema and intracranial hypertension are neurological complications responsible for substantial morbidity/mortality in patients with acute liver failure (ALF), where, aside from liver transplantation, ...
Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure
(2005-05)
BACKGROUND/AIMS: Mild hypothermia has proven useful in the clinical management of patients with acute liver failure. Acute liver failure in experimental animals results in alterations in the expression of genes coding for ...
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure
(2001-06)
Evidence from both clinical and experimental studies demonstrates that mild hypothermia prevents encephalopathy and brain edema in acute liver failure (ALF). As part of a series of studies to elucidate the mechanism(s) ...
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure
(2006-06)
BACKGROUND/AIMS: It has been proposed that, in acute liver failure, skeletal muscle adapts to become the principle organ responsible for removal of blood-borne ammonia by increasing glutamine synthesis, a reaction that is ...
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study
(2003)
Mild hypothermia has a protective effect on brain edema and encephalopathy in both experimental and human acute liver failure. The goals of the present study were to examine the effects of mild hypothermia (35°C) on brain ...
Brain edema in acute liver failure and chronic liver disease: Similarities and differences
(2013)
Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that typically develops as a result of acute liver failure or chronic liver disease. Brain edema is a common feature associated with HE. In acute liver ...
Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?
(2002)
Glutamatergic dysfunction has been suggested to play an important role in the pathogenesis of hepatic encephalopathy (HE) in acute liver failure (ALF). Increased extracellular brain glutamate concentrations have consistently ...
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure
(2001)
There is increasing evidence that central noradrenaline (NA) transport mechanisms are implicated in the central nervous system complications of acute liver failure. In order to assess this possibility, binding sites for ...