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Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide
(2005-12)
Chronic liver failure leads to hyperammonemia and consequently increased brain ammonia concentrations, resulting in hepatic encephalopathy. When the liver fails to regulate ammonia concentrations, the brain, devoid of a ...
Keeping cool in acute liver failure: rationale for the use of mild hypothermia
(2005)
Encephalopathy, brain edema and intracranial hypertension are neurological complications responsible for substantial morbidity/mortality in patients with acute liver failure (ALF), where, aside from liver transplantation, ...
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH
(2005)
Hyperammonemia is a key factor in the pathogenesis of hepatic encephalopathy (HE) as well as other metabolic encephalopathies, such as those associated with inherited disorders of urea cycle enzymes and in Reye's syndrome. ...