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Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs
(Springer, 2004-01-21)
Abstract Objective: Although water-soluble drugs can be removed by
haemofiltration/haemodialysis, morbidity and mortality from intoxication
with protein-bound drugs remains
high. The present study investigates
whether ...
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure
(2007-12)
We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP). This was independent of ...
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure
(2009-07)
Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would ...
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
(2006-01)
BACKGROUND: Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin ...
Hypothermia in acute liver failure
(2004)
The development of encephalopathy in patients with acute liver injury defines the occurrence of liver failure. The encephalopathy of acute liver failure is characterized by brain edema which manifests clinically as increased ...
Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis
(2006)
OBJECTIVE: Acute liver failure (ALF) is haemodynamically characterized by a hyperdynamic circulation. The aims of this study were to investigate the systemic and regional haemodynamics in ALF, to measure changes in nitric ...
Contractile response of femoral arteries in pigs with acute liver failure
(2004)
BACKGROUND: Acute liver failure (ALF) is characterized haemodynamically by a progressive hyperdynamic circulation. The pathophysiological mechanism is unknown, but impaired contractility of vascular smooth muscle may play ...