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Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs
(Springer, 2004-01-21)
Abstract Objective: Although water-soluble drugs can be removed by
haemofiltration/haemodialysis, morbidity and mortality from intoxication
with protein-bound drugs remains
high. The present study investigates
whether ...
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: In vivo mouse model
(2009)
The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of cancer-associated proteins, PCs play key roles in multiple steps of ...
Development and disease of the photoreceptor cilium
(2009)
Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding ...
The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition
(2009)
A role for variant histone H2A.Z in gene expression is now well established but little is known about the mechanisms by which it operates. Using a combination of ChIP-chip, knockdown and expression profiling experiments, ...
Src family kinases are required for limb trajectory selection by spinal motor axons
(2009)
Signal relay by guidance receptors at the axonal growth cone is a process essential for the assembly of a functional nervous system. We
investigated the in vivo function of Src family kinases (SFKs) as growth cone guidance ...
Active nuclear import and cytoplasmic retention of activation-induced deaminase
(2009)
The enzyme activation-induced deaminase (AID) triggers antibody diversification in B cells by catalyzing deamination and consequently mutation of immunoglobulin genes. To minimize off-target deamination, AID is restrained ...
HCO3 dependent impact of Na+,K+, 2Cl cotransport in vascular smooth muscle excitation-contraction coupling
(Krager, 2009)
In smooth muscles, inhibition of Na(+),K(+),2Cl(-) cotransport (NKCC) by bumetanide decreased intracellular Cl(-) content ([Cl(-)](i)) and suppressed the contractions triggered by diverse stimuli. This study examines whether ...
Quality of life in multiple sclerosis: translation in French Canadian of the MSQoL-54
(2003)
BACKGROUND:Multiple Sclerosis (MS) is a neurodegenerative disease which runs its course for the remainder of the patient's life frequently causing disability of varying degrees. Negative effects on Health-related quality ...
Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa
(2005)
BACKGROUND:The intratracheal instillation of Pseudomonas aeruginosa entrapped in agar beads in the mouse lung leads to chronic lung infection in susceptible mouse strains. As the infection generates a strong inflammatory ...