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Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction
(1999)
BACKGROUND & AIMS: Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional ...
Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure
(1997-07)
It has been suggested that reduced astrocytic uptake of neuronally released glutamate contributes to the pathogenesis of hepatic encephalopathy in acute liver failure. In order to further address this issue, the recently ...
L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action
(1998-06)
Strategies aimed at the lowering of blood ammonia remain the treatment of choice in portal-systemic encephalopathy (PSE). L-ornithine-L-aspartate (OA) has recently been shown to be effective in the prevention of ...
Role of manganese in the pathogenesis of portal-systemic encephalopathy
(1998-12)
Amongst the potential neurotoxins implicated in the pathogenesis of hepatic encephalopathy, manganese emerges as a new candidate. In patients with chronic liver diseases, manganese accumulates in blood and brain leading ...
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle
(1999)
The effects of chronic liver insufficiency resulting from end-to-side portacaval anastomosis (PCA) on glutamine synthetase (GS) activities, protein and gene expression were studied in brain, liver and skeletal muscle of ...