Search
Now showing items 1-10 of 13
Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs
(Springer, 2004-01-21)
Abstract Objective: Although water-soluble drugs can be removed by
haemofiltration/haemodialysis, morbidity and mortality from intoxication
with protein-bound drugs remains
high. The present study investigates
whether ...
Hepatic encephalopathy : novel insights into classification, pathophysiology and therapy
(Elsevier, 2020-10-21)
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild ...
Judging the value of ammonia measurement on lactulose dosing : apples and oranges?
(University of Toronto Press, 2021-02-24)
Heretical thoughts into hepatic encephalopathy
(Elsevier & European Association for the Study of the Liver, 2022-03-27)
Clinical progress in the development of new diagnostic modalities and therapeutic strategies for the management of patients with hepatic encephalopathy has lagged behind the vast knowledge that has been generated from basic ...
Lessons on brain edema in HE : from cellular to animal models and clinical studies
(Springer, 2023-08-22)
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations ...
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure
(2007-12)
We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP). This was independent of ...
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure
(2009-07)
Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would ...
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
(2006-01)
BACKGROUND: Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin ...