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Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure
BACKGROUND/AIMS: It has been proposed that, in acute liver failure, skeletal muscle adapts to become the principle organ responsible for removal of blood-borne ammonia by increasing glutamine synthesis, a reaction that is ...
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study
Mild hypothermia has a protective effect on brain edema and encephalopathy in both experimental and human acute liver failure. The goals of the present study were to examine the effects of mild hypothermia (35°C) on brain ...
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia
The principal cause of mortality in patients with acute liver failure (ALF) is brain herniation resulting from intracranial hypertension caused by a progressive increase of brain water. In the present study, ex vivo ...